DegronMD

Uniprot ID: O43734

Source protein: E3 ubiquitin ligase TRAF3IP2

Source gene: TRAF3IP2

Class: DEG_APCC_DBOX_1

Location: 562:570

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7921

ASA_SCORE: 89.2889

COIL: 0.9294

CONS_SCORE: 0.5726

DSS_SCORE: 0.3744

HELIX: 0.019

FCONS_SCORE: 0.9439

RIG_SCORE: 0.71

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P558H	TCGA-G7-A8LB	KIRP	TCGA	PRGPLPTLQ	DEG_APCC_DBOX_1	0.6667
p.Q570K	SIDM00898	Breast Carcinoma	GDSC	PRGPLPTLQ	DEG_APCC_DBOX_1	0.5833
p.Q570K	AU565	breast	COSMIC	PRGPLPTLQ	DEG_APCC_DBOX_1	0.5833
p.Q561K	AU565	breast	COSMIC	PRGPLPTLQ	DEG_APCC_DBOX_1	0.3056
p.Q560K	AU565	breast	COSMIC	PRGPLPTLQ	DEG_APCC_DBOX_1	0.2778
p.P557H	DO51553	KIRP	ICGC	PRGPLPTLQ	DEG_APCC_DBOX_1	0.1944
p.P555A	DO228935	COCA	ICGC	PRGPLPTLQ	DEG_APCC_DBOX_1	0.1389

Showing 1 to 7 of 7 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43734	E3 ubiquitin ligase TRAF3IP2	DEG_APCC_DBOX_1	562:570	PRGPLPTLQ	APC,CDC20,FZR1	0.7921	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons