DegronMD - O43736(ITM2A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L60P	TCGA-A5-A0G1	UCEC	TCGA	GRCMLTLLG	DEG_APCC_DBOX_1	51:59	Mutation rewiring degron network	0.3056
p.L60P	DO42472	UCEC	ICGC	GRCMLTLLG	DEG_APCC_DBOX_1	51:59	Mutation rewiring degron network	0.3056
p.Q44H	TCGA-DA-A1I1	SKCM	TCGA	GRCMLTLLG	DEG_APCC_DBOX_1	51:59	Mutation rewiring degron network	0.1389
p.Q44H	DO37966	SKCM	ICGC	GRCMLTLLG	DEG_APCC_DBOX_1	51:59	Mutation rewiring degron network	0.1389
p.E47V	TCGA-E9-A1R4	BRCA	TCGA	GRCMLTLLG	DEG_APCC_DBOX_1	51:59	Mutation rewiring degron network	0.2222
p.E47V	DO5815	BRCA	ICGC	GRCMLTLLG	DEG_APCC_DBOX_1	51:59	Mutation rewiring degron network	0.2222
p.G48V	TCGA-EO-A22X	UCEC	TCGA	GRCMLTLLG	DEG_APCC_DBOX_1	51:59	Mutation rewiring degron network	0.25
p.G48V	DO43907	UCEC	ICGC	GRCMLTLLG	DEG_APCC_DBOX_1	51:59	Mutation rewiring degron network	0.25
p.E45K	TCGA-GF-A6C9	SKCM	TCGA	GRCMLTLLG	DEG_APCC_DBOX_1	51:59	Mutation rewiring degron network	0.1667
p.E45K	DO51254	SKCM	ICGC	GRCMLTLLG	DEG_APCC_DBOX_1	51:59	Mutation rewiring degron network	0.1667
p.L64M	DO228916	LICA	ICGC	GRCMLTLLG	DEG_APCC_DBOX_1	51:59	Mutation rewiring degron network	0.1944
p.Q44K	DO229034	LICA	ICGC	GRCMLTLLG	DEG_APCC_DBOX_1	51:59	Mutation rewiring degron network	0.1389
p.K46Q	DO220855	MELA	ICGC	GRCMLTLLG	DEG_APCC_DBOX_1	51:59	Mutation substituting flanking lysine	0.3056
p.Q44R	DO229257	THCA	ICGC	GRCMLTLLG	DEG_APCC_DBOX_1	51:59	Mutation rewiring degron network	0.1389
p.G51V	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	GRCMLTLLG	DEG_APCC_DBOX_1	51:59	Mutation altering degron motif	0.6421
p.G51V	ACH-000589	Lung Cancer	CCLE	GRCMLTLLG	DEG_APCC_DBOX_1	51:59	Mutation altering degron motif	0.6421
p.G51V	NCI-H1437	lung	COSMIC	GRCMLTLLG	DEG_APCC_DBOX_1	51:59	Mutation altering degron motif	0.6421
p.S50F	ACH-000923	Lymphoma	CCLE	GRCMLTLLG	DEG_APCC_DBOX_1	51:59	Mutation rewiring degron network	0.3056

Kaplan plot for ITM2A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITM2A

UniProt ID: O43736

Entrez ID: 9452

Protein name: Integral membrane protein 2A (Protein E25)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITM2A in