DegronMD

Uniprot ID: O43736

Source protein: Integral membrane protein 2A

Source gene: ITM2A

Class: DEG_APCC_DBOX_1

Location: 51:59

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6653

ASA_SCORE: 46.2444

COIL: 0.1

CONS_SCORE: 0.5857

DSS_SCORE: 0.0494

HELIX: 0.8496

FCONS_SCORE: 1.3369

RIG_SCORE: 0.9082

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L60P	TCGA-A5-A0G1	UCEC	TCGA	GRCMLTLLG	DEG_APCC_DBOX_1	0.3056
p.L60P	DO42472	UCEC	ICGC	GRCMLTLLG	DEG_APCC_DBOX_1	0.3056
p.Q44H	TCGA-DA-A1I1	SKCM	TCGA	GRCMLTLLG	DEG_APCC_DBOX_1	0.1389
p.Q44H	DO37966	SKCM	ICGC	GRCMLTLLG	DEG_APCC_DBOX_1	0.1389
p.E47V	TCGA-E9-A1R4	BRCA	TCGA	GRCMLTLLG	DEG_APCC_DBOX_1	0.2222
p.E47V	DO5815	BRCA	ICGC	GRCMLTLLG	DEG_APCC_DBOX_1	0.2222
p.G48V	TCGA-EO-A22X	UCEC	TCGA	GRCMLTLLG	DEG_APCC_DBOX_1	0.25
p.G48V	DO43907	UCEC	ICGC	GRCMLTLLG	DEG_APCC_DBOX_1	0.25
p.E45K	TCGA-GF-A6C9	SKCM	TCGA	GRCMLTLLG	DEG_APCC_DBOX_1	0.1667
p.E45K	DO51254	SKCM	ICGC	GRCMLTLLG	DEG_APCC_DBOX_1	0.1667
p.L64M	DO228916	LICA	ICGC	GRCMLTLLG	DEG_APCC_DBOX_1	0.1944
p.Q44K	DO229034	LICA	ICGC	GRCMLTLLG	DEG_APCC_DBOX_1	0.1389
p.K46Q	DO220855	MELA	ICGC	GRCMLTLLG	DEG_APCC_DBOX_1	0.3056
p.Q44R	DO229257	THCA	ICGC	GRCMLTLLG	DEG_APCC_DBOX_1	0.1389
p.G51V	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	GRCMLTLLG	DEG_APCC_DBOX_1	0.6421
p.G51V	ACH-000589	Lung Cancer	CCLE	GRCMLTLLG	DEG_APCC_DBOX_1	0.6421
p.G51V	NCI-H1437	lung	COSMIC	GRCMLTLLG	DEG_APCC_DBOX_1	0.6421
p.S50F	ACH-000923	Lymphoma	CCLE	GRCMLTLLG	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43736	Integral membrane protein 2A	DEG_APCC_DBOX_1	51:59	GRCMLTLLG	APC,CDC20,FZR1	0.6653	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons