DegronMD - O43914(TYROBP)

FUNCTION: Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (PubMed:9490415, PubMed:9655483, PubMed:10604985). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (PubMed:9490415). Also has an inhibitory role in some cells (PubMed:21727189). Non-covalently associates with activating receptors of the CD300 family to mediate cell activation (PubMed:15557162, PubMed:16920917, PubMed:17928527; PubMed:26221034). Also mediates cell activation through association with activating receptors of the CD200R family (By similarity). Required for neutrophil activation mediated by integrin (By similarity). Required for the activation of myeloid cells mediated by the CLEC5A/MDL1 receptor (PubMed:10449773). Associates with natural killer (NK) cell receptors such as KIR2DS2 and the KLRD1/KLRC2 heterodimer to mediate NK cell activation (PubMed:9490415, PubMed:9655483, PubMed:23715743). Also enhances trafficking and cell surface expression of NK cell receptors KIR2DS1, KIR2DS2 and KIR2DS4 and ensures their stability at the cell surface (PubMed:23715743). Associates with SIRPB1 to mediate activation of myeloid cells such as monocytes and dendritic cells (PubMed:10604985). Associates with TREM1 to mediate activation of neutrophils and monocytes (PubMed:10799849). Associates with TREM2 on monocyte-derived dendritic cells to mediate up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (PubMed:11602640). Association with TREM2 mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (PubMed:18957693). Stabilizes the TREM2 C-terminal fragment (TREM2-CTF) produced by TREM2 ectodomain shedding which suppresses the release of pro-inflammatory cytokines (PubMed:25957402). In microglia, required with TREM2 for phagocytosis of apoptotic neurons (By similarity). Required with ITGAM/CD11B in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). Promotes pro-inflammatory responses in microglia following nerve injury which accelerates degeneration of injured neurons (By similarity). Positively regulates the expression of the IRAK3/IRAK-M kinase and IL10 production by liver dendritic cells and inhibits their T cell allostimulatory ability (By similarity). Negatively regulates B cell proliferation (PubMed:21727189). Required for CSF1-mediated osteoclast cytoskeletal organization (By similarity). Positively regulates multinucleation during osteoclast development (By similarity). {ECO:0000250|UniProtKB:O54885, ECO:0000269|PubMed:10449773, ECO:0000269|PubMed:10604985, ECO:0000269|PubMed:10799849, ECO:0000269|PubMed:11602640, ECO:0000269|PubMed:15557162, ECO:0000269|PubMed:16920917, ECO:0000269|PubMed:17928527, ECO:0000269|PubMed:18957693, ECO:0000269|PubMed:21727189, ECO:0000269|PubMed:23715743, ECO:0000269|PubMed:25957402, ECO:0000269|PubMed:26221034, ECO:0000269|PubMed:9490415, ECO:0000269|PubMed:9655483}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P110S	TCGA-AP-A059	UCEC	TCGA	RSDVYSD	LIG_APCC_ABBAyCdc20_2	98:104	Mutation rewiring degron network	0.1667
p.L105F	TCGA-BF-A1PX	SKCM	TCGA	RSDVYSD	LIG_APCC_ABBAyCdc20_2	98:104	Mutation rewiring degron network	0.3056
p.Q95H	TCGA-HE-7130	KIRP	TCGA	RSDVYSD	LIG_APCC_ABBAyCdc20_2	98:104	Mutation rewiring degron network	0.25
p.T92I	DO222703	COCA	ICGC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	98:104	Mutation rewiring degron network	0.1667
p.D93N	DO222884	COCA	ICGC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	98:104	Mutation rewiring degron network	0.1944
p.R114H	DO13863	GBM	ICGC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	98:104	Mutation rewiring degron network	0.0556
p.T100N	DO228985	LICA	ICGC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	98:104	Mutation altering degron motif	0.7055
p.T89K	DO229022	LICA	ICGC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.5278
p.P101Q	DO229038	LICA	ICGC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	98:104	Mutation altering degron motif	0.7035
p.H94Y	DO52365	LUSC	ICGC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	98:104	Mutation rewiring degron network	0.2222
p.H103P	DO220903	MELA	ICGC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	98:104	Mutation altering degron motif	0.7694
p.K112E	DO37474	SKCM	ICGC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	98:104	Mutation blocking phosphorylation signal	0.5556
p.D104N	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	98:104	Mutation altering degron motif	0.6932

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TYROBP

UniProt ID: O43914

Entrez ID: 7305

Protein name: TYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12) (Killer-activating receptor-associated protein) (KAR-associated protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TYROBP in