DegronMD

Uniprot ID: O43914

Source protein: TYRO protein tyrosine kinase-binding protein

Source gene: TYROBP

Class: LIG_APCC_ABBAyCdc20_2

Location: 98:104

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9646

ASA_SCORE: 81.2714

COIL: 0.6604

CONS_SCORE: 0.8184

DSS_SCORE: 0.5884

HELIX: 0.3136

FCONS_SCORE: 1.0593

RIG_SCORE: 0.7364

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P110S	TCGA-AP-A059	UCEC	TCGA	RSDVYSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.L105F	TCGA-BF-A1PX	SKCM	TCGA	RSDVYSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.Q95H	TCGA-HE-7130	KIRP	TCGA	RSDVYSD	LIG_APCC_ABBAyCdc20_2	0.25
p.T92I	DO222703	COCA	ICGC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.D93N	DO222884	COCA	ICGC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R114H	DO13863	GBM	ICGC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.T100N	DO228985	LICA	ICGC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	0.7055
p.T89K	DO229022	LICA	ICGC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	0.5278
p.P101Q	DO229038	LICA	ICGC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	0.7035
p.H94Y	DO52365	LUSC	ICGC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	0.2222
p.H103P	DO220903	MELA	ICGC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	0.7694
p.K112E	DO37474	SKCM	ICGC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	0.5556
p.D104N	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	RSDVYSD	LIG_APCC_ABBAyCdc20_2	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43914	TYRO protein tyrosine kinase-binding protein	LIG_APCC_ABBAyCdc20_2	98:104	RSDVYSD	APC,CDC20,FZR1	0.9646	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons