DegronMD - O60225(SSX5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N130K	TCGA-17-Z014	LUAD	TCGA	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.3056
p.N130K	TCGA-PJ-A5Z9	KIRP	TCGA	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.3056
p.N130K	DO44504	KIRP	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.3056
p.D119Y	TCGA-49-6744	LUAD	TCGA	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation altering degron motif	0.7325
p.P109R	TCGA-56-A4ZJ	LUSC	TCGA	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.0833
p.P109R	DO45520	LUSC	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.0833
p.R131H	TCGA-74-6584	GBM	TCGA	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.2778
p.R131H	DO12778	GBM	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.2778
p.R131H	SIDM00217	Colorectal Carcinoma	GDSC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.2778
p.R131H	SNU-1040	large intestine	COSMIC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.2778
p.P110R	TCGA-A7-A4SE	BRCA	TCGA	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation substituting flanking lysine	0.2222
p.R113H	TCGA-AA-A02O	COAD	TCGA	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.1944
p.R113H	TCGA-AP-A056	UCEC	TCGA	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.1944
p.R113H	TCGA-VQ-A8E7	STAD	TCGA	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.1944
p.R113H	DO9226	COAD	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.1944
p.R113H	DO222347	STAD	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.1944
p.R113H	DO43971	UCEC	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.1944
p.D124A	TCGA-AJ-A3EL	UCEC	TCGA	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation altering degron motif	0.7793
p.V135F	TCGA-BR-4292	STAD	TCGA	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.1667
p.F111L	TCGA-CZ-4853	KIRC	TCGA	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.1389
p.A118T	TCGA-E6-A2P8	UCEC	TCGA	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation altering degron motif	0.7139
p.A118T	TCGA-S9-A6UB	LGG	TCGA	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation altering degron motif	0.7139
p.A118T	SIDM00217	Colorectal Carcinoma	GDSC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation altering degron motif	0.7139
p.A118T	SNU-1040	large intestine	COSMIC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation altering degron motif	0.7139
p.N133D	TCGA-EO-A22U	UCEC	TCGA	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.2222
p.N133D	DO43755	UCEC	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.2222
p.R116Q	TCGA-GN-A26A	SKCM	TCGA	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.2778
p.R116Q	DO37861	SKCM	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.2778
p.D126N	TCGA-IG-A3QL	ESCA	TCGA	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation altering degron motif	0.6932
p.R113C	DO227985	COCA	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.1944
p.R113C	SIDM00505	Pancreatic Carcinoma	GDSC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.1944
p.P113S	DO14284	HNSC	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.1944
p.H137R	DO228967	LICA	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation substituting flanking lysine	0.2222
p.H137R	DO229030	LICA	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation substituting flanking lysine	0.2222
p.H137R	DO229052	LICA	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation substituting flanking lysine	0.2222
p.H137R	DO229051	LICA	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation substituting flanking lysine	0.2222
p.H137R	DO229057	LICA	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation substituting flanking lysine	0.2222
p.F108S	DO229052	LICA	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.0556
p.P129H	DO229058	LICA	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation altering degron motif	0.7694
p.V117A	DO229060	LICA	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.3056
p.G125V	DO45517	LUSC	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation altering degron motif	0.6421
p.E119K	DO47646	SKCM	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation altering degron motif	0.7022
p.G136E	DO42761	UCEC	ICGC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.1389
p.Q134H	SIDM00330	Neuroblastoma	GDSC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.1944
p.Q134H	LAN-6	autonomic ganglia	COSMIC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.1944
p.V135I	SIDM00560	Gastric Carcinoma	GDSC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.1667
p.V135I	MKN7	stomach	COSMIC	EEGNDSKGVPEA	DEG_COP1_1	118:129	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SSX5

UniProt ID: O60225

Entrez ID: 6758

Protein name: Protein SSX5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SSX5 in