DegronMD

Uniprot ID: O60225

Source protein: Protein SSX5

Source gene: SSX5

Class: DEG_COP1_1

Location: 118:129

E3 ligase: COP1

DEGRON score: 0.9667

ASA_SCORE: 90.2917

COIL: 0.8756

CONS_SCORE: 0.377

DSS_SCORE: 0.7858

HELIX: 0.0895

FCONS_SCORE: 1.2491

RIG_SCORE: 0.586

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N130K	TCGA-17-Z014	LUAD	TCGA	EEGNDSKGVPEA	DEG_COP1_1	0.3056
p.N130K	TCGA-PJ-A5Z9	KIRP	TCGA	EEGNDSKGVPEA	DEG_COP1_1	0.3056
p.N130K	DO44504	KIRP	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.3056
p.D119Y	TCGA-49-6744	LUAD	TCGA	EEGNDSKGVPEA	DEG_COP1_1	0.7325
p.P109R	TCGA-56-A4ZJ	LUSC	TCGA	EEGNDSKGVPEA	DEG_COP1_1	0.0833
p.P109R	DO45520	LUSC	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.0833
p.R131H	TCGA-74-6584	GBM	TCGA	EEGNDSKGVPEA	DEG_COP1_1	0.2778
p.R131H	DO12778	GBM	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.2778
p.R131H	SIDM00217	Colorectal Carcinoma	GDSC	EEGNDSKGVPEA	DEG_COP1_1	0.2778
p.R131H	SNU-1040	large_intestine	COSMIC	EEGNDSKGVPEA	DEG_COP1_1	0.2778
p.P110R	TCGA-A7-A4SE	BRCA	TCGA	EEGNDSKGVPEA	DEG_COP1_1	0.2222
p.R113H	TCGA-AA-A02O	COAD	TCGA	EEGNDSKGVPEA	DEG_COP1_1	0.1944
p.R113H	TCGA-AP-A056	UCEC	TCGA	EEGNDSKGVPEA	DEG_COP1_1	0.1944
p.R113H	TCGA-VQ-A8E7	STAD	TCGA	EEGNDSKGVPEA	DEG_COP1_1	0.1944
p.R113H	DO9226	COAD	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.1944
p.R113H	DO222347	STAD	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.1944
p.R113H	DO43971	UCEC	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.1944
p.D124A	TCGA-AJ-A3EL	UCEC	TCGA	EEGNDSKGVPEA	DEG_COP1_1	0.7793
p.V135F	TCGA-BR-4292	STAD	TCGA	EEGNDSKGVPEA	DEG_COP1_1	0.1667
p.F111L	TCGA-CZ-4853	KIRC	TCGA	EEGNDSKGVPEA	DEG_COP1_1	0.1389
p.A118T	TCGA-E6-A2P8	UCEC	TCGA	EEGNDSKGVPEA	DEG_COP1_1	0.7139
p.A118T	TCGA-S9-A6UB	LGG	TCGA	EEGNDSKGVPEA	DEG_COP1_1	0.7139
p.A118T	SIDM00217	Colorectal Carcinoma	GDSC	EEGNDSKGVPEA	DEG_COP1_1	0.7139
p.A118T	SNU-1040	large_intestine	COSMIC	EEGNDSKGVPEA	DEG_COP1_1	0.7139
p.N133D	TCGA-EO-A22U	UCEC	TCGA	EEGNDSKGVPEA	DEG_COP1_1	0.2222
p.N133D	DO43755	UCEC	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.2222
p.R116Q	TCGA-GN-A26A	SKCM	TCGA	EEGNDSKGVPEA	DEG_COP1_1	0.2778
p.R116Q	DO37861	SKCM	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.2778
p.D126N	TCGA-IG-A3QL	ESCA	TCGA	EEGNDSKGVPEA	DEG_COP1_1	0.6932
p.R113C	DO227985	COCA	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.1944
p.R113C	SIDM00505	Pancreatic Carcinoma	GDSC	EEGNDSKGVPEA	DEG_COP1_1	0.1944
p.P113S	DO14284	HNSC	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.1944
p.H137R	DO228967	LICA	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.2222
p.H137R	DO229030	LICA	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.2222
p.H137R	DO229052	LICA	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.2222
p.H137R	DO229051	LICA	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.2222
p.H137R	DO229057	LICA	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.2222
p.F108S	DO229052	LICA	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.0556
p.P129H	DO229058	LICA	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.7694
p.V117A	DO229060	LICA	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.3056
p.G125V	DO45517	LUSC	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.6421
p.E119K	DO47646	SKCM	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.7022
p.G136E	DO42761	UCEC	ICGC	EEGNDSKGVPEA	DEG_COP1_1	0.1389
p.Q134H	SIDM00330	Neuroblastoma	GDSC	EEGNDSKGVPEA	DEG_COP1_1	0.1944
p.Q134H	LAN-6	autonomic_ganglia	COSMIC	EEGNDSKGVPEA	DEG_COP1_1	0.1944
p.V135I	SIDM00560	Gastric Carcinoma	GDSC	EEGNDSKGVPEA	DEG_COP1_1	0.1667
p.V135I	MKN7	stomach	COSMIC	EEGNDSKGVPEA	DEG_COP1_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EEGNDSKGVPEA

Degron related mutations and impact score

Drug responses associated with SSX5 mutations

All proteins holding degron of EEGNDSKGVPEA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60225	Protein SSX5	DEG_COP1_1	118:129	EEGNDSKGVPEA	COP1	0.9667	More...