DegronMD - O60241(ADGRB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1432T	SIDM01278	Colorectal Carcinoma	GDSC	TPSARQVPEP	DEG_COP1_1	1429:1438	Mutation altering degron motif	0.6028
p.P1425L	SIDM00474	Ovarian Carcinoma	GDSC	TPSARQVPEP	DEG_COP1_1	1429:1438	Mutation rewiring degron network	0.2222
p.P1425L	OV-7	ovary	COSMIC	TPSARQVPEP	DEG_COP1_1	1429:1438	Mutation rewiring degron network	0.2222
p.W1425R	NCI-H441	lung	COSMIC	TPSARQVPEP	DEG_COP1_1	1429:1438	Mutation rewiring degron network	0.2222
p.G1424C	NCI-H838	lung	COSMIC	TPSARQVPEP	DEG_COP1_1	1429:1438	Mutation rewiring degron network	0.1944
p.L1447M	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	TPSARQVPEP	DEG_COP1_1	1429:1438	Mutation rewiring degron network	0.0833
p.Y1433H	PF-382	haematopoietic and lymphoid tissue	COSMIC	TPSARQVPEP	DEG_COP1_1	1429:1438	Mutation altering degron motif	0.7229
p.R1432Q	LU-165	lung	COSMIC	TPSARQVPEP	DEG_COP1_1	1429:1438	Mutation altering degron motif	0.7329
p.G1445C	NCI-H838	lung	COSMIC	TPSARQVPEP	DEG_COP1_1	1429:1438	Mutation rewiring degron network	0.1389
p.R1421H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	TPSARQVPEP	DEG_COP1_1	1429:1438	Mutation rewiring degron network	0.1111
p.E1448K	SNU-1040	large intestine	COSMIC	TPSARQVPEP	DEG_COP1_1	1429:1438	Mutation rewiring degron network	0.0556
p.R1448Q	MLMA	haematopoietic and lymphoid tissue	COSMIC	TPSARQVPEP	DEG_COP1_1	1429:1438	Mutation rewiring degron network	0.0556
p.R1448Q	KYSE-220	oesophagus	COSMIC	TPSARQVPEP	DEG_COP1_1	1429:1438	Mutation rewiring degron network	0.0556
p.L1426M	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	TPSARQVPEP	DEG_COP1_1	1429:1438	Mutation rewiring degron network	0.25
p.R1443P	NCI-H596	lung	COSMIC	TPSARQVPEP	DEG_COP1_1	1429:1438	Mutation rewiring degron network	0.1944
p.E1427K	SNU-1040	large intestine	COSMIC	TPSARQVPEP	DEG_COP1_1	1429:1438	Mutation rewiring degron network	0.2778

Kaplan plot for ADGRB2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADGRB2

UniProt ID: O60241

Entrez ID: 576

Protein name: Adhesion G protein-coupled receptor B2 (Brain-specific angiogenesis inhibitor 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADGRB2 in