DegronMD

Uniprot ID: O60241

Source protein: Adhesion G protein-coupled receptor B2

Source gene: ADGRB2

Class: DEG_COP1_1

Location: 1429:1438

E3 ligase: COP1

DEGRON score: 0.586

ASA_SCORE: 85.31

COIL: 0.8722

CONS_SCORE: 0.3616

DSS_SCORE: 0.8285

HELIX: 0.0469

FCONS_SCORE: 0.9919

RIG_SCORE: 0.5865

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1432T	SIDM01278	Colorectal Carcinoma	GDSC	TPSARQVPEP	DEG_COP1_1	0.6028
p.P1425L	SIDM00474	Ovarian Carcinoma	GDSC	TPSARQVPEP	DEG_COP1_1	0.2222
p.P1425L	OV-7	ovary	COSMIC	TPSARQVPEP	DEG_COP1_1	0.2222
p.W1425R	NCI-H441	lung	COSMIC	TPSARQVPEP	DEG_COP1_1	0.2222
p.G1424C	NCI-H838	lung	COSMIC	TPSARQVPEP	DEG_COP1_1	0.1944
p.L1447M	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	TPSARQVPEP	DEG_COP1_1	0.0833
p.Y1433H	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	TPSARQVPEP	DEG_COP1_1	0.7229
p.R1432Q	LU-165	lung	COSMIC	TPSARQVPEP	DEG_COP1_1	0.7329
p.G1445C	NCI-H838	lung	COSMIC	TPSARQVPEP	DEG_COP1_1	0.1389
p.R1421H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	TPSARQVPEP	DEG_COP1_1	0.1111
p.E1448K	SNU-1040	large_intestine	COSMIC	TPSARQVPEP	DEG_COP1_1	0.0556
p.R1448Q	MLMA	haematopoietic_and_lymphoid_tissue	COSMIC	TPSARQVPEP	DEG_COP1_1	0.0556
p.R1448Q	KYSE-220	oesophagus	COSMIC	TPSARQVPEP	DEG_COP1_1	0.0556
p.L1426M	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	TPSARQVPEP	DEG_COP1_1	0.25
p.R1443P	NCI-H596	lung	COSMIC	TPSARQVPEP	DEG_COP1_1	0.1944
p.E1427K	SNU-1040	large_intestine	COSMIC	TPSARQVPEP	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60241	Adhesion G protein-coupled receptor B2	DEG_COP1_1	1429:1438	TPSARQVPEP	COP1	0.586	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons