DegronMD - O60266(ADCY3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R566K	TCGA-50-6597	LUAD	TCGA	RRLRLQDLA	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.7237
p.V577L	TCGA-AX-A1CE	UCEC	TCGA	RRLRLQDLA	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.2222
p.R568C	TCGA-B3-4104	KIRP	TCGA	RRLRLQDLA	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.719
p.R568C	SIDM00947	Glioblastoma	GDSC	RRLRLQDLA	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.719
p.R568H	TCGA-BC-A69H	LIHC	TCGA	RRLRLQDLA	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.7133
p.D556N	TCGA-DU-6392	LGG	TCGA	RRLRLQDLA	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.0833
p.P558S	TCGA-F1-A448	STAD	TCGA	RRLRLQDLA	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.1389
p.S559L	TCGA-FW-A3R5	SKCM	TCGA	RRLRLQDLA	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.1667
p.A571V	DO221261	AML	ICGC	RRLRLQDLA	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.6936
p.K562I	DO233671	GACA	ICGC	RRLRLQDLA	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.25
p.T563I	DO29136	OV	ICGC	RRLRLQDLA	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.2778
p.K560T	DO52412	UCEC	ICGC	RRLRLQDLA	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.1944
p.T567M	DO52399	UCEC	ICGC	RRLRLQDLA	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.7423
p.T567M	ACH-000999	Colon/Colorectal Cancer	CCLE	RRLRLQDLA	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.7423
p.R575Q	SIDM01582	Gastric Carcinoma	GDSC	RRLRLQDLA	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.2778
p.P563S	ACH-000738	Brain Cancer	CCLE	RRLRLQDLA	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.2778
p.A570V	ACH-000999	Colon/Colorectal Cancer	CCLE	RRLRLQDLA	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.6936

Kaplan plot for ADCY3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADCY3

UniProt ID: O60266

Entrez ID: 109

Protein name: Adenylate cyclase type 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylate cyclase type III) (AC-III) (Adenylate cyclase, olfactive type) (Adenylyl cyclase 3) (AC3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADCY3 in