DegronMD

Uniprot ID: O60266

Source protein: Adenylate cyclase type 3

Source gene: ADCY3

Class: DEG_APCC_DBOX_1

Location: 565:573

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5795

ASA_SCORE: 93.3111

COIL: 0.5744

CONS_SCORE: 0.3677

DSS_SCORE: 0.5347

HELIX: 0.3474

FCONS_SCORE: 1.0038

RIG_SCORE: 0.729

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R566K	TCGA-50-6597	LUAD	TCGA	RRLRLQDLA	DEG_APCC_DBOX_1	0.7237
p.V577L	TCGA-AX-A1CE	UCEC	TCGA	RRLRLQDLA	DEG_APCC_DBOX_1	0.2222
p.R568C	TCGA-B3-4104	KIRP	TCGA	RRLRLQDLA	DEG_APCC_DBOX_1	0.719
p.R568C	SIDM00947	Glioblastoma	GDSC	RRLRLQDLA	DEG_APCC_DBOX_1	0.719
p.R568H	TCGA-BC-A69H	LIHC	TCGA	RRLRLQDLA	DEG_APCC_DBOX_1	0.7133
p.D556N	TCGA-DU-6392	LGG	TCGA	RRLRLQDLA	DEG_APCC_DBOX_1	0.0833
p.P558S	TCGA-F1-A448	STAD	TCGA	RRLRLQDLA	DEG_APCC_DBOX_1	0.1389
p.S559L	TCGA-FW-A3R5	SKCM	TCGA	RRLRLQDLA	DEG_APCC_DBOX_1	0.1667
p.A571V	DO221261	AML	ICGC	RRLRLQDLA	DEG_APCC_DBOX_1	0.6936
p.K562I	DO233671	GACA	ICGC	RRLRLQDLA	DEG_APCC_DBOX_1	0.25
p.T563I	DO29136	OV	ICGC	RRLRLQDLA	DEG_APCC_DBOX_1	0.2778
p.K560T	DO52412	UCEC	ICGC	RRLRLQDLA	DEG_APCC_DBOX_1	0.1944
p.T567M	DO52399	UCEC	ICGC	RRLRLQDLA	DEG_APCC_DBOX_1	0.7423
p.T567M	ACH-000999	Colon/Colorectal Cancer	CCLE	RRLRLQDLA	DEG_APCC_DBOX_1	0.7423
p.R575Q	SIDM01582	Gastric Carcinoma	GDSC	RRLRLQDLA	DEG_APCC_DBOX_1	0.2778
p.P563S	ACH-000738	Brain Cancer	CCLE	RRLRLQDLA	DEG_APCC_DBOX_1	0.2778
p.A570V	ACH-000999	Colon/Colorectal Cancer	CCLE	RRLRLQDLA	DEG_APCC_DBOX_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60266	Adenylate cyclase type 3	DEG_APCC_DBOX_1	565:573	RRLRLQDLA	APC,CDC20,FZR1	0.5795	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons