DegronMD - O60315(ZEB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L844S	TCGA-34-2605	LUSC	TCGA	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.1944
p.L844S	DO26471	LUSC	ICGC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.1944
p.E1105K	TCGA-55-A4DF	LUAD	TCGA	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.2222
p.E1105K	DO45318	LUAD	ICGC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.2222
p.E1105K	DO228861	MALY	ICGC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.2222
p.S851P	TCGA-61-1738	OV	TCGA	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation altering degron motif	0.6752
p.S851P	DO30380	OV	ICGC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation altering degron motif	0.6752
p.S850F	TCGA-BR-4253	STAD	TCGA	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation altering degron motif	0.6871
p.S850F	DO38455	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation altering degron motif	0.6871
p.N847T	TCGA-BR-7901	STAD	TCGA	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.2778
p.N847T	DO38463	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.2778
p.L862V	TCGA-D7-6527	STAD	TCGA	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.0833
p.L862V	DO50450	ESAD	ICGC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.0833
p.L862V	DO234463	ESAD	ICGC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.0833
p.L862V	DO38635	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.0833
p.G1099R	TCGA-EE-A29S	SKCM	TCGA	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.0556
p.G1099R	DO37936	SKCM	ICGC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.0556
p.S843G	DO218440	BTCA	ICGC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.1667
p.A1111T	DO233772	GACA	ICGC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation altering degron motif	0.6028
p.D857V	DO229044	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.2222
p.S840I	DO45117	LIRI	ICGC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation blocking phosphorylation signal	0.5278
p.D845Y	DO33176	PACA	ICGC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.2222
p.S1115C	DO229467	SKCA	ICGC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation altering degron motif	0.7541
p.P1118H	SIDM00460	B-Cell Non-Hodgkin's Lymphoma	GDSC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.3056
p.P1118H	ACH-000124	Lymphoma	CCLE	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.3056
p.P1118H	OCI-LY-19	haematopoietic and lymphoid tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.3056
p.T1117A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation altering degron motif	0.7139
p.T1117A	ACH-002256	Leukemia	CCLE	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation altering degron motif	0.7139
p.T1117A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation altering degron motif	0.7139
p.M1108V	SIDM00573	Glioblastoma	GDSC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.3056
p.M1108V	ACH-001606	Brain Cancer	CCLE	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.3056
p.M1108V	no-11	central nervous system	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.3056
p.Y1121H	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.2222
p.Y1121H	ACH-000061	Lymphoma	CCLE	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.2222
p.Y1121H	HH	haematopoietic and lymphoid tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.2222
p.D857G	SIDM01045	Endometrial Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.2222
p.D857G	ACH-000978	Endometrial/Uterine Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.2222
p.D857G	EN	endometrium	COSMIC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.2222
p.D1123H	SIDM00272	Breast Carcinoma	GDSC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.1667
p.D1123H	ACH-000910	Breast Cancer	CCLE	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.1667
p.D1123H	MDA-MB-453	breast	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.1667
p.T1117I	SIDM00537	Colorectal Carcinoma	GDSC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation altering degron motif	0.7078
p.T1117I	ACH-000982	Colon/Colorectal Cancer	CCLE	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation altering degron motif	0.7078
p.T1117I	ACH-001345	Colon/Colorectal Cancer	CCLE	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation altering degron motif	0.7078
p.T1117I	GP5d	large intestine	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation altering degron motif	0.7078
p.S851F	SIDM01770	Gastric Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation altering degron motif	0.7982
p.S851F	ACH-000908	Gastric Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation altering degron motif	0.7982
p.A839V	SIDM01611	Endometrial Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.0556
p.A839V	ACH-000996	Endometrial/Uterine Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.0556
p.L862F	ACH-000872	Lung Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.0833
p.S1115N	ACH-001061	Colon/Colorectal Cancer	CCLE	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation altering degron motif	0.7069
p.M1102V	NCI-H345	lung	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.1389
p.G851R	TE-5	oesophagus	COSMIC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation altering degron motif	0.7568
p.K842N	KM12	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.1389
p.M849V	no-11	central nervous system	COSMIC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation altering degron motif	0.7208
p.A1120V	CTV-1	haematopoietic and lymphoid tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.25
p.D1122H	MDA-MB-453	breast	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation blocking phosphorylation signal	0.6389
p.K1105R	Daudi	haematopoietic and lymphoid tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.2222
p.M1107V	no-11	central nervous system	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.2778
p.T1116I	GP5d	large intestine	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation altering degron motif	0.7078
p.A857T	MN-60	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.2222
p.T858I	GP5d	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.1944
p.S1122R	Daudi	haematopoietic and lymphoid tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation blocking phosphorylation signal	0.6389
p.T1116A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation altering degron motif	0.7139
p.E1119K	BT-20	breast	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.2778
p.T858A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.1944
p.E1127D	NCI-H23	lung	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.0556
p.E1104D	NCI-H23	lung	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.1944
p.D856G	EN	endometrium	COSMIC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.25
p.A1107V	WM-115	skin	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.2778
p.P1117H	OCI-LY-19	haematopoietic and lymphoid tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation altering degron motif	0.7694
p.D1099H	MDA-MB-453	breast	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.0556
p.Y862H	HH	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.0833
p.S1123T	Daudi	haematopoietic and lymphoid tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.1667
p.S1113N	DJM-1	skin	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation altering degron motif	0.7069
p.Y1120H	HH	haematopoietic and lymphoid tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	1109:1117	Mutation rewiring degron network	0.25
p.P859H	OCI-LY-19	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	849:853	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZEB2

UniProt ID: O60315

Entrez ID: 9839

Protein name: Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZEB2 in