DegronMD

Uniprot ID: O60315

Source protein: Zinc finger E-box-binding homeobox 2

Source gene: ZEB2

Class: DEG_APCC_DBOX_1

Location: 1109:1117

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.995

ASA_SCORE: 82

COIL: 0.7109

CONS_SCORE: 0.261

DSS_SCORE: 0.5921

HELIX: 0.1034

FCONS_SCORE: 1.0002

RIG_SCORE: 0.7362

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1105K	TCGA-55-A4DF	LUAD	TCGA	NRAYLQSIT	DEG_APCC_DBOX_1	0.2222
p.E1105K	DO45318	LUAD	ICGC	NRAYLQSIT	DEG_APCC_DBOX_1	0.2222
p.E1105K	DO228861	MALY	ICGC	NRAYLQSIT	DEG_APCC_DBOX_1	0.2222
p.G1099R	TCGA-EE-A29S	SKCM	TCGA	NRAYLQSIT	DEG_APCC_DBOX_1	0.0556
p.G1099R	DO37936	SKCM	ICGC	NRAYLQSIT	DEG_APCC_DBOX_1	0.0556
p.A1111T	DO233772	GACA	ICGC	NRAYLQSIT	DEG_APCC_DBOX_1	0.6028
p.S1115C	DO229467	SKCA	ICGC	NRAYLQSIT	DEG_APCC_DBOX_1	0.7541
p.P1118H	SIDM00460	B-Cell Non-Hodgkin's Lymphoma	GDSC	NRAYLQSIT	DEG_APCC_DBOX_1	0.3056
p.P1118H	ACH-000124	Lymphoma	CCLE	NRAYLQSIT	DEG_APCC_DBOX_1	0.3056
p.P1118H	OCI-LY-19	haematopoietic_and_lymphoid_tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.3056
p.T1117A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	NRAYLQSIT	DEG_APCC_DBOX_1	0.7139
p.T1117A	ACH-002256	Leukemia	CCLE	NRAYLQSIT	DEG_APCC_DBOX_1	0.7139
p.T1117A	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.7139
p.M1108V	SIDM00573	Glioblastoma	GDSC	NRAYLQSIT	DEG_APCC_DBOX_1	0.3056
p.M1108V	ACH-001606	Brain Cancer	CCLE	NRAYLQSIT	DEG_APCC_DBOX_1	0.3056
p.M1108V	no-11	central_nervous_system	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.3056
p.Y1121H	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	NRAYLQSIT	DEG_APCC_DBOX_1	0.2222
p.Y1121H	ACH-000061	Lymphoma	CCLE	NRAYLQSIT	DEG_APCC_DBOX_1	0.2222
p.Y1121H	HH	haematopoietic_and_lymphoid_tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.2222
p.D1123H	SIDM00272	Breast Carcinoma	GDSC	NRAYLQSIT	DEG_APCC_DBOX_1	0.1667
p.D1123H	ACH-000910	Breast Cancer	CCLE	NRAYLQSIT	DEG_APCC_DBOX_1	0.1667
p.D1123H	MDA-MB-453	breast	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.1667
p.T1117I	SIDM00537	Colorectal Carcinoma	GDSC	NRAYLQSIT	DEG_APCC_DBOX_1	0.7078
p.T1117I	ACH-000982	Colon/Colorectal Cancer	CCLE	NRAYLQSIT	DEG_APCC_DBOX_1	0.7078
p.T1117I	ACH-001345	Colon/Colorectal Cancer	CCLE	NRAYLQSIT	DEG_APCC_DBOX_1	0.7078
p.T1117I	GP5d	large_intestine	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.7078
p.S1115N	ACH-001061	Colon/Colorectal Cancer	CCLE	NRAYLQSIT	DEG_APCC_DBOX_1	0.7069
p.M1102V	NCI-H345	lung	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.1389
p.A1120V	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.25
p.D1122H	MDA-MB-453	breast	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.6389
p.K1105R	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.2222
p.M1107V	no-11	central_nervous_system	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.2778
p.T1116I	GP5d	large_intestine	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.7078
p.S1122R	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.6389
p.T1116A	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.7139
p.E1119K	BT-20	breast	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.2778
p.E1127D	NCI-H23	lung	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.0556
p.E1104D	NCI-H23	lung	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.1944
p.A1107V	WM-115	skin	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.2778
p.P1117H	OCI-LY-19	haematopoietic_and_lymphoid_tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.7694
p.D1099H	MDA-MB-453	breast	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.0556
p.S1123T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.1667
p.S1113N	DJM-1	skin	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.7069
p.Y1120H	HH	haematopoietic_and_lymphoid_tissue	COSMIC	NRAYLQSIT	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NRAYLQSIT

Degron related mutations and impact score

Drug responses associated with ZEB2 mutations

All proteins holding degron of NRAYLQSIT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60315	Zinc finger E-box-binding homeobox 2	DEG_APCC_DBOX_1	1109:1117	NRAYLQSIT	APC,CDC20,FZR1	0.995	More...