DegronMD - O60391(GRIN3B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R864H	TCGA-13-A5FT	OV	TCGA	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.7133
p.R864H	TCGA-D5-6928	COAD	TCGA	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.7133
p.R864H	DO7776	COAD	ICGC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.7133
p.R864H	DO50082	OV	ICGC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.7133
p.R864C	TCGA-AP-A0LM	UCEC	TCGA	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.719
p.R864C	DO43306	UCEC	ICGC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.719
p.S867N	DO228935	COCA	ICGC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.25
p.G851A	DO234199	ESAD	ICGC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.1944
p.R862C	DO233652	GACA	ICGC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.719
p.L860Q	DO233898	GACA	ICGC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.7765
p.A854T	DO42304	UCEC	ICGC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.2778
p.A854T	SIDM00132	Pancreatic Carcinoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.2778
p.A854T	ACH-000535	Pancreatic Cancer	CCLE	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.2778
p.E852K	SIDM00845	Burkitt's Lymphoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.2222
p.E852K	SIDM00087	Plasma Cell Myeloma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.2222
p.E852K	SIDM01112	Osteosarcoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.2222
p.E852K	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.2222
p.E852K	SIDM00844	Burkitt's Lymphoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.2222
p.E852K	SIDM00930	Osteosarcoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.2222
p.E852K	SIDM00068	Colorectal Carcinoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.2222
p.E852K	SIDM00863	Burkitt's Lymphoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.2222
p.E852K	SIDM01686	Chronic Myelogenous Leukemia	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.2222
p.E852K	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.2222
p.E852K	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.2222
p.H874D	SIDM01181	Hepatocellular Carcinoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.0556
p.R857C	ACH-000299	Leukemia	CCLE	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.8301
p.Y871H	ACH-000937	Leukemia	CCLE	FRLALPRIR	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.1389

Kaplan plot for GRIN3B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GRIN3B

UniProt ID: O60391

Entrez ID: 116444

Protein name: Glutamate receptor ionotropic, NMDA 3B (GluN3B) (N-methyl-D-aspartate receptor subtype 3B) (NMDAR3B) (NR3B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GRIN3B in