DegronMD

Uniprot ID: O60391

Source protein: Glutamate receptor ionotropic, NMDA 3B

Source gene: GRIN3B

Class: DEG_APCC_DBOX_1

Location: 856:864

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8768

ASA_SCORE: 75.1333

COIL: 0.374

CONS_SCORE: 0.6768

DSS_SCORE: 0.0347

HELIX: 0.6033

FCONS_SCORE: 1.2786

RIG_SCORE: 0.8794

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R864H	TCGA-13-A5FT	OV	TCGA	FRLALPRIR	DEG_APCC_DBOX_1	0.7133
p.R864H	TCGA-D5-6928	COAD	TCGA	FRLALPRIR	DEG_APCC_DBOX_1	0.7133
p.R864H	DO7776	COAD	ICGC	FRLALPRIR	DEG_APCC_DBOX_1	0.7133
p.R864H	DO50082	OV	ICGC	FRLALPRIR	DEG_APCC_DBOX_1	0.7133
p.R864C	TCGA-AP-A0LM	UCEC	TCGA	FRLALPRIR	DEG_APCC_DBOX_1	0.719
p.R864C	DO43306	UCEC	ICGC	FRLALPRIR	DEG_APCC_DBOX_1	0.719
p.S867N	DO228935	COCA	ICGC	FRLALPRIR	DEG_APCC_DBOX_1	0.25
p.G851A	DO234199	ESAD	ICGC	FRLALPRIR	DEG_APCC_DBOX_1	0.1944
p.R862C	DO233652	GACA	ICGC	FRLALPRIR	DEG_APCC_DBOX_1	0.719
p.L860Q	DO233898	GACA	ICGC	FRLALPRIR	DEG_APCC_DBOX_1	0.7765
p.A854T	DO42304	UCEC	ICGC	FRLALPRIR	DEG_APCC_DBOX_1	0.2778
p.A854T	SIDM00132	Pancreatic Carcinoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	0.2778
p.A854T	ACH-000535	Pancreatic Cancer	CCLE	FRLALPRIR	DEG_APCC_DBOX_1	0.2778
p.E852K	SIDM00845	Burkitt's Lymphoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	0.2222
p.E852K	SIDM00087	Plasma Cell Myeloma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	0.2222
p.E852K	SIDM01112	Osteosarcoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	0.2222
p.E852K	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	0.2222
p.E852K	SIDM00844	Burkitt's Lymphoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	0.2222
p.E852K	SIDM00930	Osteosarcoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	0.2222
p.E852K	SIDM00068	Colorectal Carcinoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	0.2222
p.E852K	SIDM00863	Burkitt's Lymphoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	0.2222
p.E852K	SIDM01686	Chronic Myelogenous Leukemia	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	0.2222
p.E852K	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	0.2222
p.E852K	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	0.2222
p.H874D	SIDM01181	Hepatocellular Carcinoma	GDSC	FRLALPRIR	DEG_APCC_DBOX_1	0.0556
p.R857C	ACH-000299	Leukemia	CCLE	FRLALPRIR	DEG_APCC_DBOX_1	0.8301
p.Y871H	ACH-000937	Leukemia	CCLE	FRLALPRIR	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FRLALPRIR

Degron related mutations and impact score

Drug responses associated with GRIN3B mutations

All proteins holding degron of FRLALPRIR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60391	Glutamate receptor ionotropic, NMDA 3B	DEG_APCC_DBOX_1	856:864	FRLALPRIR	APC,CDC20,FZR1	0.8768	More...