DegronMD - O60447(EVI5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S74A	TCGA-94-8035	LUSC	TCGA	LSTPALS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.25
p.S74A	DO219173	LUSC	ICGC	LSTPALS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.25
p.S122L	TCGA-AR-A0TX	BRCA	TCGA	VSSSS	DEG_SPOP_SBC_1	118:122	Mutation altering degron motif	0.7667
p.S122L	DO1663	BRCA	ICGC	VSSSS	DEG_SPOP_SBC_1	118:122	Mutation altering degron motif	0.7667
p.L56S	TCGA-B5-A1MX	UCEC	TCGA	LSTPALS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.0833
p.L56S	DO41999	UCEC	ICGC	LSTPALS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.0833
p.S115F	TCGA-DK-A1AC	BLCA	TCGA	VSSSS	DEG_SPOP_SBC_1	118:122	Mutation blocking phosphorylation signal	0.6944
p.S115F	DO514	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	118:122	Mutation blocking phosphorylation signal	0.6944
p.P68S	TCGA-EE-A29E	SKCM	TCGA	LSTPALS	DEG_SCF_FBW7_1	65:71	Mutation altering degron motif	0.6752
p.P68S	DO37831	SKCM	ICGC	LSTPALS	DEG_SCF_FBW7_1	65:71	Mutation altering degron motif	0.6752
p.S121L	TCGA-FD-A3SS	BLCA	TCGA	VSSSS	DEG_SPOP_SBC_1	118:122	Mutation altering degron motif	0.7667
p.S121L	DO737	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	118:122	Mutation altering degron motif	0.7667
p.S120R	DO222637	BTCA	ICGC	VSSSS	DEG_SPOP_SBC_1	118:122	Mutation altering degron motif	0.7427
p.S121P	DO233884	GACA	ICGC	VSSSS	DEG_SPOP_SBC_1	118:122	Mutation altering degron motif	0.6752
p.A69D	DO228948	LICA	ICGC	LSTPALS	DEG_SCF_FBW7_1	65:71	Mutation altering degron motif	0.6682
p.A123T	DO50970	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	118:122	Mutation rewiring degron network	0.3056
p.S76L	DO222402	MELA	ICGC	LSTPALS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.1944
p.L78F	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSTPALS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.1389
p.L78F	ACH-002221	Lymphoma	CCLE	LSTPALS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.1389
p.L78F	CTB-1	haematopoietic and lymphoid tissue	COSMIC	LSTPALS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.1389
p.S119L	SIDM00217	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	118:122	Mutation altering degron motif	0.6556
p.S119L	ACH-000999	Colon/Colorectal Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	118:122	Mutation altering degron motif	0.6556
p.S119L	SNU-1040	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	118:122	Mutation altering degron motif	0.6556
p.S62C	SIDM00861	Ovarian Carcinoma	GDSC	LSTPALS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.25
p.S62C	ACH-000906	Ovarian Cancer	CCLE	LSTPALS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.25
p.S62C	ES-2	ovary	COSMIC	LSTPALS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.25
p.H57D	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	LSTPALS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.1111
p.Q77K	SIDM01519	Head and Neck Carcinoma	GDSC	LSTPALS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.1667
p.T58I	SIDM01619	Endometrial Carcinoma	GDSC	LSTPALS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.1389
p.T58I	ACH-000984	Endometrial/Uterine Cancer	CCLE	LSTPALS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.1389

Kaplan plot for EVI5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EVI5

UniProt ID: O60447

Entrez ID: 7813

Protein name: Ecotropic viral integration site 5 protein homolog (EVI-5) (Neuroblastoma stage 4S gene protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EVI5 in