DegronMD

Uniprot ID: O60447

Source protein: Ecotropic viral integration site 5 protein homolog

Source gene: EVI5

Class: DEG_SCF_FBW7_1

Location: 65:71

E3 ligase: FBXW7

DEGRON score: 0.9557

ASA_SCORE: 92.9571

COIL: 0.9726

CONS_SCORE: 0.2604

DSS_SCORE: 0.6373

HELIX: 0.0124

FCONS_SCORE: 1.0099

RIG_SCORE: 0.5961

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S74A	TCGA-94-8035	LUSC	TCGA	LSTPALS	DEG_SCF_FBW7_1	0.25
p.S74A	DO219173	LUSC	ICGC	LSTPALS	DEG_SCF_FBW7_1	0.25
p.L56S	TCGA-B5-A1MX	UCEC	TCGA	LSTPALS	DEG_SCF_FBW7_1	0.0833
p.L56S	DO41999	UCEC	ICGC	LSTPALS	DEG_SCF_FBW7_1	0.0833
p.P68S	TCGA-EE-A29E	SKCM	TCGA	LSTPALS	DEG_SCF_FBW7_1	0.6752
p.P68S	DO37831	SKCM	ICGC	LSTPALS	DEG_SCF_FBW7_1	0.6752
p.A69D	DO228948	LICA	ICGC	LSTPALS	DEG_SCF_FBW7_1	0.6682
p.S76L	DO222402	MELA	ICGC	LSTPALS	DEG_SCF_FBW7_1	0.1944
p.L78F	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSTPALS	DEG_SCF_FBW7_1	0.1389
p.L78F	ACH-002221	Lymphoma	CCLE	LSTPALS	DEG_SCF_FBW7_1	0.1389
p.L78F	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPALS	DEG_SCF_FBW7_1	0.1389
p.S62C	SIDM00861	Ovarian Carcinoma	GDSC	LSTPALS	DEG_SCF_FBW7_1	0.25
p.S62C	ACH-000906	Ovarian Cancer	CCLE	LSTPALS	DEG_SCF_FBW7_1	0.25
p.S62C	ES-2	ovary	COSMIC	LSTPALS	DEG_SCF_FBW7_1	0.25
p.H57D	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	LSTPALS	DEG_SCF_FBW7_1	0.1111
p.Q77K	SIDM01519	Head and Neck Carcinoma	GDSC	LSTPALS	DEG_SCF_FBW7_1	0.1667
p.T58I	SIDM01619	Endometrial Carcinoma	GDSC	LSTPALS	DEG_SCF_FBW7_1	0.1389
p.T58I	ACH-000984	Endometrial/Uterine Cancer	CCLE	LSTPALS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60447	Ecotropic viral integration site 5 protein homolog	DEG_SCF_FBW7_1	65:71	LSTPALS	FBXW7	0.9557	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons