DegronMD - O60479(DLX3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D49N	TCGA-BR-8081	STAD	TCGA	DYYSGQP	CBL_PTK	49:55	Mutation altering degron motif	0.5821
p.D49N	DO38795	STAD	ICGC	DYYSGQP	CBL_PTK	49:55	Mutation altering degron motif	0.5821
p.G53D	TCGA-DF-A2KU	UCEC	TCGA	DYYSGQP	CBL_PTK	49:55	Mutation altering degron motif	0.6087
p.G53D	DO223286	UCEC	ICGC	DYYSGQP	CBL_PTK	49:55	Mutation altering degron motif	0.6087
p.A45T	TCGA-EO-A22R	UCEC	TCGA	DYYSGQP	CBL_PTK	49:55	Mutation rewiring degron network	0.2222
p.A45T	DO42713	UCEC	ICGC	DYYSGQP	CBL_PTK	49:55	Mutation rewiring degron network	0.2222
p.A40V	DO804	BLCA	ICGC	DYYSGQP	CBL_PTK	49:55	Mutation rewiring degron network	0.0833
p.R39C	DO233205	GACA	ICGC	DYYSGQP	CBL_PTK	49:55	Mutation rewiring degron network	0.0556
p.R60C	DO233828	GACA	ICGC	DYYSGQP	CBL_PTK	49:55	Mutation rewiring degron network	0.1944
p.A43V	DO11854	GBM	ICGC	DYYSGQP	CBL_PTK	49:55	Mutation rewiring degron network	0.1667
p.F57Y	DO18036	KIRC	ICGC	DYYSGQP	CBL_PTK	49:55	Mutation rewiring degron network	0.2778
p.S44R	DO229031	LICA	ICGC	DYYSGQP	CBL_PTK	49:55	Mutation rewiring degron network	0.1944
p.S44R	DO229008	LICA	ICGC	DYYSGQP	CBL_PTK	49:55	Mutation rewiring degron network	0.1944
p.P62T	DO229038	LICA	ICGC	DYYSGQP	CBL_PTK	49:55	Mutation rewiring degron network	0.1389
p.R61C	DO26846	LUSC	ICGC	DYYSGQP	CBL_PTK	49:55	Mutation rewiring degron network	0.1667
p.R61C	DO47849	STAD	ICGC	DYYSGQP	CBL_PTK	49:55	Mutation rewiring degron network	0.1667
p.A43D	DO36366	PRAD	ICGC	DYYSGQP	CBL_PTK	49:55	Mutation rewiring degron network	0.1667
p.R61S	DO51407	PRAD	ICGC	DYYSGQP	CBL_PTK	49:55	Mutation rewiring degron network	0.1667
p.K65N	DO42793	UCEC	ICGC	DYYSGQP	CBL_PTK	49:55	Mutation rewiring degron network	0.0556
p.G41D	SIDM02015	Colorectal Carcinoma	GDSC	DYYSGQP	CBL_PTK	49:55	Mutation rewiring degron network	0.1111
p.D49G	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	DYYSGQP	CBL_PTK	49:55	Mutation altering degron motif	0.7198
p.D49G	ACH-000916	Lung Cancer	CCLE	DYYSGQP	CBL_PTK	49:55	Mutation altering degron motif	0.7198
p.D49G	NCI-H1573	lung	COSMIC	DYYSGQP	CBL_PTK	49:55	Mutation altering degron motif	0.7198
p.A44T	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	DYYSGQP	CBL_PTK	49:55	Mutation rewiring degron network	0.1944

Kaplan plot for DLX3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DLX3

UniProt ID: O60479

Entrez ID: 1747

Protein name: Homeobox protein DLX-3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DLX3 in