DegronMD

Uniprot ID: O60479

Source protein: Homeobox protein DLX-3

Source gene: DLX3

Class: CBL_PTK

Location: 49:55

E3 ligase: CBL

DEGRON score: 0.679

ASA_SCORE: 29.8429

COIL: 0.8917

CONS_SCORE: 0.5376

DSS_SCORE: 0.439

HELIX: 0.0473

FCONS_SCORE: 0.9454

RIG_SCORE: 0.7158

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D49N	TCGA-BR-8081	STAD	TCGA	DYYSGQP	CBL_PTK	0.5821
p.D49N	DO38795	STAD	ICGC	DYYSGQP	CBL_PTK	0.5821
p.G53D	TCGA-DF-A2KU	UCEC	TCGA	DYYSGQP	CBL_PTK	0.6087
p.G53D	DO223286	UCEC	ICGC	DYYSGQP	CBL_PTK	0.6087
p.A45T	TCGA-EO-A22R	UCEC	TCGA	DYYSGQP	CBL_PTK	0.2222
p.A45T	DO42713	UCEC	ICGC	DYYSGQP	CBL_PTK	0.2222
p.A40V	DO804	BLCA	ICGC	DYYSGQP	CBL_PTK	0.0833
p.R39C	DO233205	GACA	ICGC	DYYSGQP	CBL_PTK	0.0556
p.R60C	DO233828	GACA	ICGC	DYYSGQP	CBL_PTK	0.1944
p.A43V	DO11854	GBM	ICGC	DYYSGQP	CBL_PTK	0.1667
p.F57Y	DO18036	KIRC	ICGC	DYYSGQP	CBL_PTK	0.2778
p.S44R	DO229031	LICA	ICGC	DYYSGQP	CBL_PTK	0.1944
p.S44R	DO229008	LICA	ICGC	DYYSGQP	CBL_PTK	0.1944
p.P62T	DO229038	LICA	ICGC	DYYSGQP	CBL_PTK	0.1389
p.R61C	DO26846	LUSC	ICGC	DYYSGQP	CBL_PTK	0.1667
p.R61C	DO47849	STAD	ICGC	DYYSGQP	CBL_PTK	0.1667
p.A43D	DO36366	PRAD	ICGC	DYYSGQP	CBL_PTK	0.1667
p.R61S	DO51407	PRAD	ICGC	DYYSGQP	CBL_PTK	0.1667
p.K65N	DO42793	UCEC	ICGC	DYYSGQP	CBL_PTK	0.0556
p.G41D	SIDM02015	Colorectal Carcinoma	GDSC	DYYSGQP	CBL_PTK	0.1111
p.D49G	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	DYYSGQP	CBL_PTK	0.7198
p.D49G	ACH-000916	Lung Cancer	CCLE	DYYSGQP	CBL_PTK	0.7198
p.D49G	NCI-H1573	lung	COSMIC	DYYSGQP	CBL_PTK	0.7198
p.A44T	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DYYSGQP	CBL_PTK	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60479	Homeobox protein DLX-3	CBL_PTK	49:55	DYYSGQP	CBL	0.679	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons