DegronMD - O60496(DOK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A160D	TCGA-BS-A0UV	UCEC	TCGA	VGPHKE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.0556
p.A142T	TCGA-D1-A17R	UCEC	TCGA	VGPHKE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.25
p.A142T	TCGA-OR-A5KB	ACC	TCGA	VGPHKE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.25
p.A142T	DO233188	GACA	ICGC	VGPHKE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.25
p.A142T	DO232761	PBCA	ICGC	VGPHKE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.25
p.A142T	DO41062	UCEC	ICGC	VGPHKE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.25
p.V147M	DO49890	CESC	ICGC	VGPHKE	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.7208
p.T144K	DO229036	LICA	ICGC	VGPHKE	LIG_APCC_ABBA_1	145:150	Mutation blocking phosphorylation signal	0.75
p.F160V	DO52674	MALY	ICGC	VGPHKE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.0556
p.E150K	DO222708	MELA	ICGC	VGPHKE	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.7022
p.G143E	DO219385	PRAD	ICGC	VGPHKE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2778
p.R154S	DO38332	STAD	ICGC	VGPHKE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2222
p.K158N	DO42713	UCEC	ICGC	VGPHKE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons