DegronMD

Uniprot ID: O60496

Source protein: Docking protein 2

Source gene: DOK2

Class: LIG_APCC_ABBA_1

Location: 145:150

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9594

ASA_SCORE: 60.7667

COIL: 0.6135

CONS_SCORE: 0.3334

DSS_SCORE: 0.4411

HELIX: 0.0513

FCONS_SCORE: 0.5516

RIG_SCORE: 0.7172

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A160D	TCGA-BS-A0UV	UCEC	TCGA	VGPHKE	LIG_APCC_ABBA_1	0.0556
p.A142T	TCGA-D1-A17R	UCEC	TCGA	VGPHKE	LIG_APCC_ABBA_1	0.25
p.A142T	TCGA-OR-A5KB	ACC	TCGA	VGPHKE	LIG_APCC_ABBA_1	0.25
p.A142T	DO233188	GACA	ICGC	VGPHKE	LIG_APCC_ABBA_1	0.25
p.A142T	DO232761	PBCA	ICGC	VGPHKE	LIG_APCC_ABBA_1	0.25
p.A142T	DO41062	UCEC	ICGC	VGPHKE	LIG_APCC_ABBA_1	0.25
p.V147M	DO49890	CESC	ICGC	VGPHKE	LIG_APCC_ABBA_1	0.7208
p.T144K	DO229036	LICA	ICGC	VGPHKE	LIG_APCC_ABBA_1	0.75
p.F160V	DO52674	MALY	ICGC	VGPHKE	LIG_APCC_ABBA_1	0.0556
p.E150K	DO222708	MELA	ICGC	VGPHKE	LIG_APCC_ABBA_1	0.7022
p.G143E	DO219385	PRAD	ICGC	VGPHKE	LIG_APCC_ABBA_1	0.2778
p.R154S	DO38332	STAD	ICGC	VGPHKE	LIG_APCC_ABBA_1	0.2222
p.K158N	DO42713	UCEC	ICGC	VGPHKE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60496	Docking protein 2	LIG_APCC_ABBA_1	145:150	VGPHKE	APC,CDC20,FZR1	0.9594	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons