DegronMD - O60506(SYNCRIP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D430N	TCGA-AA-3984	COAD	TCGA	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.6932
p.D430N	TCGA-DK-AA6R	BLCA	TCGA	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.6932
p.D430N	DO219006	BLCA	ICGC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.6932
p.D430N	DO9002	COAD	ICGC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.6932
p.E415Q	TCGA-AA-A017	COAD	TCGA	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.0833
p.E415Q	DO7782	COAD	ICGC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.0833
p.D430G	TCGA-AJ-A2QO	UCEC	TCGA	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.7198
p.D430G	DO42177	UCEC	ICGC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.7198
p.Y428F	DO231992	LICA	ICGC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.6417
p.P437T	DO228948	LICA	ICGC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.1389
p.A418D	DO229022	LICA	ICGC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.1667
p.A422E	DO229027	LICA	ICGC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.2778
p.D429E	DO229041	LICA	ICGC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.5647
p.H438R	SIDM00537	Colorectal Carcinoma	GDSC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.1111
p.H438R	ACH-000982	Colon/Colorectal Cancer	CCLE	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.1111
p.H438R	ACH-001345	Colon/Colorectal Cancer	CCLE	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.1111
p.H438R	GP5d	large intestine	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.1111
p.G429E	JiyoyeP-2003	haematopoietic and lymphoid tissue	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.7199
p.G429E	OVCA420	ovary	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.7199
p.G429E	COLO-680N	oesophagus	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.7199
p.G429E	NCI-H2172	lung	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.7199
p.R420L	OVCA420	ovary	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.2222
p.R420L	NCI-H2172	lung	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.2222
p.R420L	COLO-680N	oesophagus	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.2222
p.G421R	ST486	haematopoietic and lymphoid tissue	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.25
p.A440V	CW-2	large intestine	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.0556
p.V437I	Daoy	central nervous system	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.1389
p.R438Q	ES3	bone	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.1111
p.Q427H	NCI-H322M	lung	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.7582

Kaplan plot for SYNCRIP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYNCRIP

UniProt ID: O60506

Entrez ID: 10492

Protein name: Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYNCRIP in