DegronMD

Uniprot ID: O60506

Source protein: Heterogeneous nuclear ribonucleoprotein Q

Source gene: SYNCRIP

Class: LIG_APCC_ABBAyCdc20_2

Location: 424:430

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9959

ASA_SCORE: 105.1286

COIL: 0.7097

CONS_SCORE: 0.4343

DSS_SCORE: 0.5176

HELIX: 0.2796

FCONS_SCORE: 0.9926

RIG_SCORE: 0.744

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D430N	TCGA-AA-3984	COAD	TCGA	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D430N	TCGA-DK-AA6R	BLCA	TCGA	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D430N	DO219006	BLCA	ICGC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D430N	DO9002	COAD	ICGC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.6932
p.E415Q	TCGA-AA-A017	COAD	TCGA	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.0833
p.E415Q	DO7782	COAD	ICGC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D430G	TCGA-AJ-A2QO	UCEC	TCGA	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.7198
p.D430G	DO42177	UCEC	ICGC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.7198
p.Y428F	DO231992	LICA	ICGC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.6417
p.P437T	DO228948	LICA	ICGC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A418D	DO229022	LICA	ICGC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.A422E	DO229027	LICA	ICGC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D429E	DO229041	LICA	ICGC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.5647
p.H438R	SIDM00537	Colorectal Carcinoma	GDSC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.H438R	ACH-000982	Colon/Colorectal Cancer	CCLE	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.H438R	ACH-001345	Colon/Colorectal Cancer	CCLE	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.H438R	GP5d	large_intestine	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G429E	JiyoyeP-2003	haematopoietic_and_lymphoid_tissue	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.7199
p.G429E	OVCA420	ovary	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.7199
p.G429E	COLO-680N	oesophagus	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.7199
p.G429E	NCI-H2172	lung	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.7199
p.R420L	OVCA420	ovary	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R420L	NCI-H2172	lung	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R420L	COLO-680N	oesophagus	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.2222
p.G421R	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.25
p.A440V	CW-2	large_intestine	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.0556
p.V437I	Daoy	central_nervous_system	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R438Q	ES3	bone	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q427H	NCI-H322M	lung	COSMIC	KNQMYDD	LIG_APCC_ABBAyCdc20_2	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KNQMYDD

Degron related mutations and impact score

Drug responses associated with SYNCRIP mutations

All proteins holding degron of KNQMYDD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60506	Heterogeneous nuclear ribonucleoprotein Q	LIG_APCC_ABBAyCdc20_2	424:430	KNQMYDD	APC,CDC20,FZR1	0.9959	More...