DegronMD - O60522(TDRD6)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R433H	TCGA-17-Z015	LUAD	TCGA	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.1389
p.R433H	TCGA-BR-4368	STAD	TCGA	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.1389
p.R433H	DO38715	STAD	ICGC	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.1389
p.R433H	SIDM00717	Non-Cancerous	GDSC	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.1389
p.R433H	SIDM00733	Small Cell Lung Carcinoma	GDSC	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.1389
p.R433H	ACH-000525	Lung Cancer	CCLE	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.1389
p.R433H	ACH-002372	Non-Cancerous	CCLE	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.1389
p.H417Y	TCGA-49-AAR2	LUAD	TCGA	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.2222
p.H417Y	DO218918	LUAD	ICGC	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.2222
p.H417Y	SIDM00867	Glioblastoma	GDSC	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.2222
p.H417Y	ACH-000863	Brain Cancer	CCLE	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.2222
p.H417Y	DBTRG-05MG	central nervous system	COSMIC	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.2222
p.Y424H	TCGA-A5-A0G2	UCEC	TCGA	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation altering degron motif	0.6118
p.Y424H	DO41235	UCEC	ICGC	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation altering degron motif	0.6118
p.S414T	TCGA-AO-A03P	BRCA	TCGA	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.1389
p.S414T	DO5633	BRCA	ICGC	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.1389
p.F411C	TCGA-AP-A1E0	UCEC	TCGA	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.0556
p.F411C	DO43154	UCEC	ICGC	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.0556
p.H417R	TCGA-BH-A0BC	BRCA	TCGA	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.2222
p.H417R	DO4817	BRCA	ICGC	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.2222
p.G425E	TCGA-EK-A3GK	CESC	TCGA	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation altering degron motif	0.6087
p.G425E	DO49964	CESC	ICGC	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation altering degron motif	0.6087
p.Y419C	SIDM00961	Ewing's Sarcoma	GDSC	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.2778
p.Y419C	SIDM00617	Hepatocellular Carcinoma	GDSC	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.2778
p.Y419C	SIDM01444	Glioblastoma	GDSC	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.2778
p.Y420C	SIDM00444	Esophageal Carcinoma	GDSC	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.3056
p.Y420C	SIDM01148	Plasma Cell Myeloma	GDSC	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.3056
p.G436A	SIDM00123	Kidney Carcinoma	GDSC	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.0556
p.G436A	ACH-000046	Kidney Cancer	CCLE	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.0556
p.G436A	ACHN	kidney	COSMIC	VSLYGE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.0556

Kaplan plot for TDRD6 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TDRD6

UniProt ID: O60522

Entrez ID: 221400

Protein name: Tudor domain-containing protein 6 (Antigen NY-CO-45) (Cancer/testis antigen 41.2) (CT41.2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TDRD6 in