DegronMD

Uniprot ID: O60522

Source protein: Tudor domain-containing protein 6

Source gene: TDRD6

Class: LIG_APCC_ABBA_1

Location: 421:426

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5587

ASA_SCORE: 35.2167

COIL: 0.3615

CONS_SCORE: 0.5315

DSS_SCORE: 0.0115

HELIX: 0.0192

FCONS_SCORE: 1.2779

RIG_SCORE: 0.9119

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R433H	TCGA-17-Z015	LUAD	TCGA	VSLYGE	LIG_APCC_ABBA_1	0.1389
p.R433H	TCGA-BR-4368	STAD	TCGA	VSLYGE	LIG_APCC_ABBA_1	0.1389
p.R433H	DO38715	STAD	ICGC	VSLYGE	LIG_APCC_ABBA_1	0.1389
p.R433H	SIDM00717	Non-Cancerous	GDSC	VSLYGE	LIG_APCC_ABBA_1	0.1389
p.R433H	SIDM00733	Small Cell Lung Carcinoma	GDSC	VSLYGE	LIG_APCC_ABBA_1	0.1389
p.R433H	ACH-000525	Lung Cancer	CCLE	VSLYGE	LIG_APCC_ABBA_1	0.1389
p.R433H	ACH-002372	Non-Cancerous	CCLE	VSLYGE	LIG_APCC_ABBA_1	0.1389
p.H417Y	TCGA-49-AAR2	LUAD	TCGA	VSLYGE	LIG_APCC_ABBA_1	0.2222
p.H417Y	DO218918	LUAD	ICGC	VSLYGE	LIG_APCC_ABBA_1	0.2222
p.H417Y	SIDM00867	Glioblastoma	GDSC	VSLYGE	LIG_APCC_ABBA_1	0.2222
p.H417Y	ACH-000863	Brain Cancer	CCLE	VSLYGE	LIG_APCC_ABBA_1	0.2222
p.H417Y	DBTRG-05MG	central_nervous_system	COSMIC	VSLYGE	LIG_APCC_ABBA_1	0.2222
p.Y424H	TCGA-A5-A0G2	UCEC	TCGA	VSLYGE	LIG_APCC_ABBA_1	0.6118
p.Y424H	DO41235	UCEC	ICGC	VSLYGE	LIG_APCC_ABBA_1	0.6118
p.S414T	TCGA-AO-A03P	BRCA	TCGA	VSLYGE	LIG_APCC_ABBA_1	0.1389
p.S414T	DO5633	BRCA	ICGC	VSLYGE	LIG_APCC_ABBA_1	0.1389
p.F411C	TCGA-AP-A1E0	UCEC	TCGA	VSLYGE	LIG_APCC_ABBA_1	0.0556
p.F411C	DO43154	UCEC	ICGC	VSLYGE	LIG_APCC_ABBA_1	0.0556
p.H417R	TCGA-BH-A0BC	BRCA	TCGA	VSLYGE	LIG_APCC_ABBA_1	0.2222
p.H417R	DO4817	BRCA	ICGC	VSLYGE	LIG_APCC_ABBA_1	0.2222
p.G425E	TCGA-EK-A3GK	CESC	TCGA	VSLYGE	LIG_APCC_ABBA_1	0.6087
p.G425E	DO49964	CESC	ICGC	VSLYGE	LIG_APCC_ABBA_1	0.6087
p.Y419C	SIDM00961	Ewing's Sarcoma	GDSC	VSLYGE	LIG_APCC_ABBA_1	0.2778
p.Y419C	SIDM00617	Hepatocellular Carcinoma	GDSC	VSLYGE	LIG_APCC_ABBA_1	0.2778
p.Y419C	SIDM01444	Glioblastoma	GDSC	VSLYGE	LIG_APCC_ABBA_1	0.2778
p.Y420C	SIDM00444	Esophageal Carcinoma	GDSC	VSLYGE	LIG_APCC_ABBA_1	0.3056
p.Y420C	SIDM01148	Plasma Cell Myeloma	GDSC	VSLYGE	LIG_APCC_ABBA_1	0.3056
p.G436A	SIDM00123	Kidney Carcinoma	GDSC	VSLYGE	LIG_APCC_ABBA_1	0.0556
p.G436A	ACH-000046	Kidney Cancer	CCLE	VSLYGE	LIG_APCC_ABBA_1	0.0556
p.G436A	ACHN	kidney	COSMIC	VSLYGE	LIG_APCC_ABBA_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSLYGE

Degron related mutations and impact score

Drug responses associated with TDRD6 mutations

All proteins holding degron of VSLYGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60522	Tudor domain-containing protein 6	LIG_APCC_ABBA_1	421:426	VSLYGE	APC,CDC20,FZR1	0.5587	More...