DegronMD - O60609(GFRA3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E78D	TCGA-B5-A3FC	UCEC	TCGA	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation rewiring degron network	0.3056
p.E78D	DO41871	UCEC	ICGC	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation rewiring degron network	0.3056
p.S81L	TCGA-EE-A3JA	SKCM	TCGA	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation rewiring degron network	0.2222
p.S81L	DO47625	SKCM	ICGC	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation rewiring degron network	0.2222
p.S81L	ACH-001991	Primary	CCLE	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation rewiring degron network	0.2222
p.V82I	TCGA-EE-A3JE	SKCM	TCGA	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation rewiring degron network	0.1944
p.V82I	DO48766	SKCM	ICGC	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation rewiring degron network	0.1944
p.P83S	TCGA-FW-A3R5	SKCM	TCGA	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation rewiring degron network	0.1667
p.P83S	DO37406	SKCM	ICGC	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation rewiring degron network	0.1667
p.S70R	DO234300	ESAD	ICGC	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation rewiring degron network	0.3056
p.S70R	DO229022	LICA	ICGC	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation rewiring degron network	0.3056
p.P80T	DO228948	LICA	ICGC	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation rewiring degron network	0.25
p.H63N	DO229015	LICA	ICGC	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation rewiring degron network	0.1111
p.P74S	DO222413	MELA	ICGC	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation altering degron motif	0.6752
p.Y61D	DO46685	PACA	ICGC	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation rewiring degron network	0.0556
p.T73I	SIDM01307	Colorectal Carcinoma	GDSC	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation altering degron motif	0.7078
p.P80S	SIDM01175	Other Sarcomas	GDSC	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation rewiring degron network	0.25
p.P80S	ACH-002309	Sarcoma	CCLE	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation rewiring degron network	0.25
p.P80S	SW684	soft tissue	COSMIC	ISTPLPS	DEG_SCF_FBW7_1	71:77	Mutation rewiring degron network	0.25

Kaplan plot for GFRA3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GFRA3

UniProt ID: O60609

Entrez ID: 2676

Protein name: GDNF family receptor alpha-3 (GDNF receptor alpha-3) (GDNFR-alpha-3) (GFR-alpha-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GFRA3 in