DegronMD

Uniprot ID: O60609

Source protein: GDNF family receptor alpha-3

Source gene: GFRA3

Class: DEG_SCF_FBW7_1

Location: 71:77

E3 ligase: FBXW7

DEGRON score: 0.6033

ASA_SCORE: 79.5571

COIL: 0.9053

CONS_SCORE: 0.6949

DSS_SCORE: 0.4307

HELIX: 0.0646

FCONS_SCORE: 0.9715

RIG_SCORE: 0.6167

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E78D	TCGA-B5-A3FC	UCEC	TCGA	ISTPLPS	DEG_SCF_FBW7_1	0.3056
p.E78D	DO41871	UCEC	ICGC	ISTPLPS	DEG_SCF_FBW7_1	0.3056
p.S81L	TCGA-EE-A3JA	SKCM	TCGA	ISTPLPS	DEG_SCF_FBW7_1	0.2222
p.S81L	DO47625	SKCM	ICGC	ISTPLPS	DEG_SCF_FBW7_1	0.2222
p.S81L	ACH-001991	Primary	CCLE	ISTPLPS	DEG_SCF_FBW7_1	0.2222
p.V82I	TCGA-EE-A3JE	SKCM	TCGA	ISTPLPS	DEG_SCF_FBW7_1	0.1944
p.V82I	DO48766	SKCM	ICGC	ISTPLPS	DEG_SCF_FBW7_1	0.1944
p.P83S	TCGA-FW-A3R5	SKCM	TCGA	ISTPLPS	DEG_SCF_FBW7_1	0.1667
p.P83S	DO37406	SKCM	ICGC	ISTPLPS	DEG_SCF_FBW7_1	0.1667
p.S70R	DO234300	ESAD	ICGC	ISTPLPS	DEG_SCF_FBW7_1	0.3056
p.S70R	DO229022	LICA	ICGC	ISTPLPS	DEG_SCF_FBW7_1	0.3056
p.P80T	DO228948	LICA	ICGC	ISTPLPS	DEG_SCF_FBW7_1	0.25
p.H63N	DO229015	LICA	ICGC	ISTPLPS	DEG_SCF_FBW7_1	0.1111
p.P74S	DO222413	MELA	ICGC	ISTPLPS	DEG_SCF_FBW7_1	0.6752
p.Y61D	DO46685	PACA	ICGC	ISTPLPS	DEG_SCF_FBW7_1	0.0556
p.T73I	SIDM01307	Colorectal Carcinoma	GDSC	ISTPLPS	DEG_SCF_FBW7_1	0.7078
p.P80S	SIDM01175	Other Sarcomas	GDSC	ISTPLPS	DEG_SCF_FBW7_1	0.25
p.P80S	ACH-002309	Sarcoma	CCLE	ISTPLPS	DEG_SCF_FBW7_1	0.25
p.P80S	SW684	soft_tissue	COSMIC	ISTPLPS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60609	GDNF family receptor alpha-3	DEG_SCF_FBW7_1	71:77	ISTPLPS	FBXW7	0.6033	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons