DegronMD - O60645(EXOC3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A722T	TCGA-AA-3864	COAD	TCGA	VPLFKD	LIG_APCC_ABBA_1	727:732	Mutation rewiring degron network	0.1944
p.A722T	DO8490	COAD	ICGC	VPLFKD	LIG_APCC_ABBA_1	727:732	Mutation rewiring degron network	0.1944
p.S723N	TCGA-CN-6021	HNSC	TCGA	VPLFKD	LIG_APCC_ABBA_1	727:732	Mutation blocking phosphorylation signal	0.6667
p.S723N	DO15847	HNSC	ICGC	VPLFKD	LIG_APCC_ABBA_1	727:732	Mutation blocking phosphorylation signal	0.6667
p.L738V	DO222465	ESCA	ICGC	VPLFKD	LIG_APCC_ABBA_1	727:732	Mutation rewiring degron network	0.1667
p.A720S	DO229029	LICA	ICGC	VPLFKD	LIG_APCC_ABBA_1	727:732	Mutation rewiring degron network	0.1389
p.V735L	DO229063	LICA	ICGC	VPLFKD	LIG_APCC_ABBA_1	727:732	Mutation rewiring degron network	0.25
p.N739S	DO232224	PBCA	ICGC	VPLFKD	LIG_APCC_ABBA_1	727:732	Mutation rewiring degron network	0.1389
p.S737N	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VPLFKD	LIG_APCC_ABBA_1	727:732	Mutation rewiring degron network	0.1944
p.S737N	ACH-000983	Leukemia	CCLE	VPLFKD	LIG_APCC_ABBA_1	727:732	Mutation rewiring degron network	0.1944
p.S737N	KCL-22	haematopoietic and lymphoid tissue	COSMIC	VPLFKD	LIG_APCC_ABBA_1	727:732	Mutation rewiring degron network	0.1944
p.V727M	SIDM01619	Endometrial Carcinoma	GDSC	VPLFKD	LIG_APCC_ABBA_1	727:732	Mutation altering degron motif	0.6097
p.V727M	ACH-000984	Endometrial/Uterine Cancer	CCLE	VPLFKD	LIG_APCC_ABBA_1	727:732	Mutation altering degron motif	0.6097

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons