DegronMD

Uniprot ID: O60645

Source protein: Exocyst complex component 3

Source gene: EXOC3

Class: LIG_APCC_ABBA_1

Location: 727:732

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5651

ASA_SCORE: 60.0667

COIL: 0.5958

CONS_SCORE: 0.2492

DSS_SCORE: 0.1645

HELIX: 0.0377

FCONS_SCORE: 0.6911

RIG_SCORE: 0.8454

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A722T	TCGA-AA-3864	COAD	TCGA	VPLFKD	LIG_APCC_ABBA_1	0.1944
p.A722T	DO8490	COAD	ICGC	VPLFKD	LIG_APCC_ABBA_1	0.1944
p.S723N	TCGA-CN-6021	HNSC	TCGA	VPLFKD	LIG_APCC_ABBA_1	0.6667
p.S723N	DO15847	HNSC	ICGC	VPLFKD	LIG_APCC_ABBA_1	0.6667
p.L738V	DO222465	ESCA	ICGC	VPLFKD	LIG_APCC_ABBA_1	0.1667
p.A720S	DO229029	LICA	ICGC	VPLFKD	LIG_APCC_ABBA_1	0.1389
p.V735L	DO229063	LICA	ICGC	VPLFKD	LIG_APCC_ABBA_1	0.25
p.N739S	DO232224	PBCA	ICGC	VPLFKD	LIG_APCC_ABBA_1	0.1389
p.S737N	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VPLFKD	LIG_APCC_ABBA_1	0.1944
p.S737N	ACH-000983	Leukemia	CCLE	VPLFKD	LIG_APCC_ABBA_1	0.1944
p.S737N	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	VPLFKD	LIG_APCC_ABBA_1	0.1944
p.V727M	SIDM01619	Endometrial Carcinoma	GDSC	VPLFKD	LIG_APCC_ABBA_1	0.6097
p.V727M	ACH-000984	Endometrial/Uterine Cancer	CCLE	VPLFKD	LIG_APCC_ABBA_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60645	Exocyst complex component 3	LIG_APCC_ABBA_1	727:732	VPLFKD	APC,CDC20,FZR1	0.5651	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons