DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VPLFKD
Uniprot ID:
O60645
Source protein:
Exocyst complex component 3
Source gene:
EXOC3
Class:
LIG_APCC_ABBA_1
Location:
727:732
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5651
ASA_SCORE:
60.0667
COIL:
0.5958
CONS_SCORE:
0.2492
DSS_SCORE:
0.1645
HELIX:
0.0377
FCONS_SCORE:
0.6911
RIG_SCORE:
0.8454
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S723N
TCGA-CN-6021
HNSC
TCGA
VPLFKD
LIG_APCC_ABBA_1
0.6667
p.S723N
DO15847
HNSC
ICGC
VPLFKD
LIG_APCC_ABBA_1
0.6667
p.V727M
SIDM01619
Endometrial Carcinoma
GDSC
VPLFKD
LIG_APCC_ABBA_1
0.6097
p.V727M
ACH-000984
Endometrial/Uterine Cancer
CCLE
VPLFKD
LIG_APCC_ABBA_1
0.6097
p.V735L
DO229063
LICA
ICGC
VPLFKD
LIG_APCC_ABBA_1
0.25
p.A722T
TCGA-AA-3864
COAD
TCGA
VPLFKD
LIG_APCC_ABBA_1
0.1944
p.A722T
DO8490
COAD
ICGC
VPLFKD
LIG_APCC_ABBA_1
0.1944
p.S737N
SIDM01004
Chronic Myelogenous Leukemia
GDSC
VPLFKD
LIG_APCC_ABBA_1
0.1944
p.S737N
ACH-000983
Leukemia
CCLE
VPLFKD
LIG_APCC_ABBA_1
0.1944
p.S737N
KCL-22
haematopoietic_and_lymphoid_tissue
COSMIC
VPLFKD
LIG_APCC_ABBA_1
0.1944
p.L738V
DO222465
ESCA
ICGC
VPLFKD
LIG_APCC_ABBA_1
0.1667
p.A720S
DO229029
LICA
ICGC
VPLFKD
LIG_APCC_ABBA_1
0.1389
p.N739S
DO232224
PBCA
ICGC
VPLFKD
LIG_APCC_ABBA_1
0.1389
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Drug responses associated with EXOC3 mutations
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Cancer
Mutation (In Degron?)
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IC50
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All proteins holding degron of VPLFKD
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60645
Exocyst complex component 3
LIG_APCC_ABBA_1
727:732
VPLFKD
APC,CDC20,FZR1
0.5651
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