FCMR
UniProt ID: O60667
Entrez ID: 9214
Protein name: Fas apoptotic inhibitory molecule 3 (IgM Fc fragment receptor) (Regulator of Fas-induced apoptosis Toso)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rat...
FUNCTION: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. {ECO:0000269|PubMed:9586636}.
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GO - Biological processes (BP):
cellular defense response [GO:0006968]; immune system process [GO:0002376]; negative regulation of apoptotic process [GO:0043066]...
cellular defense response [GO:0006968]; immune system process [GO:0002376]; negative regulation of apoptotic process [GO:0043066]
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GO - Molecular function (MF):
transmembrane signaling receptor activity [GO:0004888]...
transmembrane signaling receptor activity [GO:0004888]
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GO - Cellular component (CC):
extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]...
extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]
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FCMR
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*NOTE: the Kaplan plots were collected from OncoLnc