DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NNIYSACP
Uniprot ID:
O60667
Source protein:
Fas apoptotic inhibitory molecule 3
Source gene:
FCMR
Class:
CBL_PTK
Location:
312:319
E3 ligase:
CBL
DEGRON score:
0.9994
ASA_SCORE:
72.55
COIL:
0.7735
CONS_SCORE:
0.8948
DSS_SCORE:
0.6767
HELIX:
0.1295
FCONS_SCORE:
1.3791
RIG_SCORE:
0.688
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R323S
SIDM00180
Kidney Carcinoma
GDSC
NNIYSACP
CBL_PTK
0.2222
p.P308T
SIDM01073
Other Blood Cancers
GDSC
NNIYSACP
CBL_PTK
0.2222
p.P308T
SIDM00893
Breast Carcinoma
GDSC
NNIYSACP
CBL_PTK
0.2222
p.R307P
SIDM00292
Small Cell Lung Carcinoma
GDSC
NNIYSACP
CBL_PTK
0.1944
p.R307P
SIDM00574
Glioblastoma
GDSC
NNIYSACP
CBL_PTK
0.1944
p.R307P
SIDM00306
Non-Small Cell Lung Carcinoma
GDSC
NNIYSACP
CBL_PTK
0.1944
Drug responses associated with FCMR mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NNIYSACP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60667
Fas apoptotic inhibitory molecule 3
CBL_PTK
312:319
NNIYSACP
CBL
0.9994
More...
