DegronMD - O60678(PRMT3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D456Y	TCGA-66-2785	LUSC	TCGA	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation altering degron motif	0.6214
p.T449M	TCGA-AD-A5EJ	COAD	TCGA	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.1667
p.T449M	SIDM00958	Chronic Myelogenous Leukemia	GDSC	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.1667
p.T449M	CML-T1	haematopoietic and lymphoid tissue	COSMIC	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.1667
p.F469L	TCGA-AX-A06F	UCEC	TCGA	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.0833
p.R466S	TCGA-ZG-A8QW	PRAD	TCGA	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.1667
p.R451C	DO6240	BRCA	ICGC	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.2222
p.T465S	DO7454	CLLE	ICGC	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.1944
p.S446N	DO229010	COCA	ICGC	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.0833
p.S446N	DO229013	COCA	ICGC	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.0833
p.S446N	DO229016	COCA	ICGC	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.0833
p.S446N	DO229003	COCA	ICGC	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.0833
p.S446N	DO229005	COCA	ICGC	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.0833
p.N460Y	DO48884	LUAD	ICGC	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation altering degron motif	0.7059
p.Q464E	DO230961	LUSC	ICGC	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.2222
p.T465P	DO37299	READ	ICGC	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.1944
p.S462L	DO37444	SKCM	ICGC	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.2778
p.Q469K	DO37901	SKCM	ICGC	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.0833
p.L457P	DO41361	UCEC	ICGC	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation altering degron motif	0.7582
p.L468F	DO41331	UCEC	ICGC	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.1111
p.A452S	SIDM01297	Colorectal Carcinoma	GDSC	FDIYFE	LIG_APCC_ABBA_1	455:460	Mutation rewiring degron network	0.25

Kaplan plot for PRMT3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRMT3

UniProt ID: O60678

Entrez ID: 10196

Protein name: Protein arginine N-methyltransferase 3 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRMT3 in