DegronMD

Uniprot ID: O60678

Source protein: Protein arginine N-methyltransferase 3

Source gene: PRMT3

Class: LIG_APCC_ABBA_1

Location: 455:460

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6083

ASA_SCORE: 40.75

COIL: 0.258

CONS_SCORE: 0.6723

DSS_SCORE: 0.0285

HELIX: 0.0052

FCONS_SCORE: 1.4939

RIG_SCORE: 0.9634

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L457P	DO41361	UCEC	ICGC	FDIYFE	LIG_APCC_ABBA_1	0.7582
p.N460Y	DO48884	LUAD	ICGC	FDIYFE	LIG_APCC_ABBA_1	0.7059
p.D456Y	TCGA-66-2785	LUSC	TCGA	FDIYFE	LIG_APCC_ABBA_1	0.6214
p.S462L	DO37444	SKCM	ICGC	FDIYFE	LIG_APCC_ABBA_1	0.2778
p.A452S	SIDM01297	Colorectal Carcinoma	GDSC	FDIYFE	LIG_APCC_ABBA_1	0.25
p.R451C	DO6240	BRCA	ICGC	FDIYFE	LIG_APCC_ABBA_1	0.2222
p.Q464E	DO230961	LUSC	ICGC	FDIYFE	LIG_APCC_ABBA_1	0.2222
p.T465S	DO7454	CLLE	ICGC	FDIYFE	LIG_APCC_ABBA_1	0.1944
p.T465P	DO37299	READ	ICGC	FDIYFE	LIG_APCC_ABBA_1	0.1944
p.T449M	TCGA-AD-A5EJ	COAD	TCGA	FDIYFE	LIG_APCC_ABBA_1	0.1667
p.T449M	SIDM00958	Chronic Myelogenous Leukemia	GDSC	FDIYFE	LIG_APCC_ABBA_1	0.1667
p.T449M	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	FDIYFE	LIG_APCC_ABBA_1	0.1667
p.R466S	TCGA-ZG-A8QW	PRAD	TCGA	FDIYFE	LIG_APCC_ABBA_1	0.1667
p.L468F	DO41331	UCEC	ICGC	FDIYFE	LIG_APCC_ABBA_1	0.1111
p.F469L	TCGA-AX-A06F	UCEC	TCGA	FDIYFE	LIG_APCC_ABBA_1	0.0833
p.S446N	DO229010	COCA	ICGC	FDIYFE	LIG_APCC_ABBA_1	0.0833
p.S446N	DO229013	COCA	ICGC	FDIYFE	LIG_APCC_ABBA_1	0.0833
p.S446N	DO229016	COCA	ICGC	FDIYFE	LIG_APCC_ABBA_1	0.0833
p.S446N	DO229003	COCA	ICGC	FDIYFE	LIG_APCC_ABBA_1	0.0833
p.S446N	DO229005	COCA	ICGC	FDIYFE	LIG_APCC_ABBA_1	0.0833
p.Q469K	DO37901	SKCM	ICGC	FDIYFE	LIG_APCC_ABBA_1	0.0833

Showing 1 to 21 of 21 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60678	Protein arginine N-methyltransferase 3	LIG_APCC_ABBA_1	455:460	FDIYFE	APC,CDC20,FZR1	0.6083	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons