DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
FDIYFE
Uniprot ID:
O60678
Source protein:
Protein arginine N-methyltransferase 3
Source gene:
PRMT3
Class:
LIG_APCC_ABBA_1
Location:
455:460
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6083
ASA_SCORE:
40.75
COIL:
0.258
CONS_SCORE:
0.6723
DSS_SCORE:
0.0285
HELIX:
0.0052
FCONS_SCORE:
1.4939
RIG_SCORE:
0.9634
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D456Y
TCGA-66-2785
LUSC
TCGA
FDIYFE
LIG_APCC_ABBA_1
0.6214
p.T449M
TCGA-AD-A5EJ
COAD
TCGA
FDIYFE
LIG_APCC_ABBA_1
0.1667
p.T449M
SIDM00958
Chronic Myelogenous Leukemia
GDSC
FDIYFE
LIG_APCC_ABBA_1
0.1667
p.T449M
CML-T1
haematopoietic_and_lymphoid_tissue
COSMIC
FDIYFE
LIG_APCC_ABBA_1
0.1667
p.F469L
TCGA-AX-A06F
UCEC
TCGA
FDIYFE
LIG_APCC_ABBA_1
0.0833
p.R466S
TCGA-ZG-A8QW
PRAD
TCGA
FDIYFE
LIG_APCC_ABBA_1
0.1667
p.R451C
DO6240
BRCA
ICGC
FDIYFE
LIG_APCC_ABBA_1
0.2222
p.T465S
DO7454
CLLE
ICGC
FDIYFE
LIG_APCC_ABBA_1
0.1944
p.S446N
DO229010
COCA
ICGC
FDIYFE
LIG_APCC_ABBA_1
0.0833
p.S446N
DO229013
COCA
ICGC
FDIYFE
LIG_APCC_ABBA_1
0.0833
p.S446N
DO229016
COCA
ICGC
FDIYFE
LIG_APCC_ABBA_1
0.0833
p.S446N
DO229003
COCA
ICGC
FDIYFE
LIG_APCC_ABBA_1
0.0833
p.S446N
DO229005
COCA
ICGC
FDIYFE
LIG_APCC_ABBA_1
0.0833
p.N460Y
DO48884
LUAD
ICGC
FDIYFE
LIG_APCC_ABBA_1
0.7059
p.Q464E
DO230961
LUSC
ICGC
FDIYFE
LIG_APCC_ABBA_1
0.2222
p.T465P
DO37299
READ
ICGC
FDIYFE
LIG_APCC_ABBA_1
0.1944
p.S462L
DO37444
SKCM
ICGC
FDIYFE
LIG_APCC_ABBA_1
0.2778
p.Q469K
DO37901
SKCM
ICGC
FDIYFE
LIG_APCC_ABBA_1
0.0833
p.L457P
DO41361
UCEC
ICGC
FDIYFE
LIG_APCC_ABBA_1
0.7582
p.L468F
DO41331
UCEC
ICGC
FDIYFE
LIG_APCC_ABBA_1
0.1111
p.A452S
SIDM01297
Colorectal Carcinoma
GDSC
FDIYFE
LIG_APCC_ABBA_1
0.25
Drug responses associated with PRMT3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FDIYFE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60678
Protein arginine N-methyltransferase 3
LIG_APCC_ABBA_1
455:460
FDIYFE
APC,CDC20,FZR1
0.6083
More...