DegronMD - O60682(MSC)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V34I	TCGA-44-8117	LUAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.5965
p.V34I	TCGA-NC-A5HR	LUSC	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.5965
p.V34I	DO233766	GACA	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.5965
p.V34I	DO24028	LUAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.5965
p.V34I	DO219203	LUSC	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.5965
p.V34I	SIDM00216	Colorectal Carcinoma	GDSC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.5965
p.V34I	SIDM01259	B-Lymphoblastic Leukemia	GDSC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.5965
p.V34I	ACH-000989	Colon/Colorectal Cancer	CCLE	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.5965
p.V34I	ACH-001669	Leukemia	CCLE	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.5965
p.V34I	ACH-002238	Leukemia	CCLE	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.5965
p.V34I	SNU-175	large intestine	COSMIC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.5965
p.V34I	GR-ST	haematopoietic and lymphoid tissue	COSMIC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.5965
p.E35G	TCGA-44-8119	LUAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.6087
p.E35G	DO24399	LUAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.6087
p.S45T	TCGA-77-6844	LUSC	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation blocking phosphorylation signal	0.5
p.S45T	DO26818	LUSC	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation blocking phosphorylation signal	0.5
p.A25T	TCGA-AA-3526	COAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.2778
p.A25T	TCGA-NH-A50V	COAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.2778
p.A25T	TCGA-R5-A7O7	STAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.2778
p.A25T	DO44094	COAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.2778
p.A25T	DO10084	COAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.2778
p.A25T	DO222339	STAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.2778
p.R32C	TCGA-AA-3947	COAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.719
p.R32C	DO8192	COAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.719
p.R28K	TCGA-BT-A42E	BLCA	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7237
p.R28K	DO44030	BLCA	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7237
p.R19L	TCGA-D9-A1X3	SKCM	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1111
p.R19L	DO37456	SKCM	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1111
p.P22Q	TCGA-DZ-6133	KIRP	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1944
p.P22Q	DO20762	KIRP	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1944
p.S45L	TCGA-EO-A3AS	UCEC	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation blocking phosphorylation signal	0.5
p.S45L	DO43466	UCEC	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation blocking phosphorylation signal	0.5
p.P29L	TCGA-HU-A4GT	STAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.6471
p.P29L	DO48020	STAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.6471
p.P22L	TCGA-HU-A4GX	STAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1944
p.P22L	DO47757	STAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1944
p.G33D	DO234389	ESAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.6087
p.R19W	DO218547	GACA	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1111
p.S42G	DO50927	LICA	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1389
p.V23L	DO45289	LIRI	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.2222
p.S26Y	DO50721	ORCA	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.3056
p.S37I	DO229211	THCA	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.2778
p.R32H	SIDM01378	Ovarian Carcinoma	GDSC	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7133
p.R32H	ACH-000646	Ovarian Cancer	CCLE	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation altering degron motif	0.7133
p.P41S	ACH-001061	Colon/Colorectal Cancer	CCLE	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.1667
p.R36H	ACH-001664	Gastric Cancer	CCLE	KRPPLRGVE	DEG_APCC_DBOX_1	27:35	Mutation rewiring degron network	0.3056

Kaplan plot for MSC in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MSC

UniProt ID: O60682

Entrez ID: 9242

Protein name: Musculin (Activated B-cell factor 1) (ABF-1) (Class A basic helix-loop-helix protein 22) (bHLHa22)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MSC in