DegronMD

Uniprot ID: O60682

Source protein: Musculin

Source gene: MSC

Class: DEG_APCC_DBOX_1

Location: 27:35

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9947

ASA_SCORE: 98.3333

COIL: 0.9119

CONS_SCORE: 0.343

DSS_SCORE: 0.6182

HELIX: 0.0383

FCONS_SCORE: 1.002

RIG_SCORE: 0.6151

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V34I	TCGA-44-8117	LUAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	TCGA-NC-A5HR	LUSC	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	DO233766	GACA	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	DO24028	LUAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	DO219203	LUSC	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	SIDM00216	Colorectal Carcinoma	GDSC	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	SIDM01259	B-Lymphoblastic Leukemia	GDSC	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	ACH-000989	Colon/Colorectal Cancer	CCLE	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	ACH-001669	Leukemia	CCLE	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	ACH-002238	Leukemia	CCLE	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	SNU-175	large_intestine	COSMIC	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.E35G	TCGA-44-8119	LUAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.6087
p.E35G	DO24399	LUAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.6087
p.S45T	TCGA-77-6844	LUSC	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.5
p.S45T	DO26818	LUSC	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.5
p.A25T	TCGA-AA-3526	COAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.2778
p.A25T	TCGA-NH-A50V	COAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.2778
p.A25T	TCGA-R5-A7O7	STAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.2778
p.A25T	DO44094	COAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.2778
p.A25T	DO10084	COAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.2778
p.A25T	DO222339	STAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.2778
p.R32C	TCGA-AA-3947	COAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.719
p.R32C	DO8192	COAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.719
p.R28K	TCGA-BT-A42E	BLCA	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.7237
p.R28K	DO44030	BLCA	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.7237
p.R19L	TCGA-D9-A1X3	SKCM	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.1111
p.R19L	DO37456	SKCM	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.1111
p.P22Q	TCGA-DZ-6133	KIRP	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.1944
p.P22Q	DO20762	KIRP	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.1944
p.S45L	TCGA-EO-A3AS	UCEC	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.5
p.S45L	DO43466	UCEC	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.5
p.P29L	TCGA-HU-A4GT	STAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.6471
p.P29L	DO48020	STAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.6471
p.P22L	TCGA-HU-A4GX	STAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.1944
p.P22L	DO47757	STAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.1944
p.G33D	DO234389	ESAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.6087
p.R19W	DO218547	GACA	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.1111
p.S42G	DO50927	LICA	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.1389
p.V23L	DO45289	LIRI	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.2222
p.S26Y	DO50721	ORCA	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.3056
p.S37I	DO229211	THCA	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.2778
p.R32H	SIDM01378	Ovarian Carcinoma	GDSC	KRPPLRGVE	DEG_APCC_DBOX_1	0.7133
p.R32H	ACH-000646	Ovarian Cancer	CCLE	KRPPLRGVE	DEG_APCC_DBOX_1	0.7133
p.P41S	ACH-001061	Colon/Colorectal Cancer	CCLE	KRPPLRGVE	DEG_APCC_DBOX_1	0.1667
p.R36H	ACH-001664	Gastric Cancer	CCLE	KRPPLRGVE	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRPPLRGVE

Degron related mutations and impact score

Drug responses associated with MSC mutations

All proteins holding degron of KRPPLRGVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60682	Musculin	DEG_APCC_DBOX_1	27:35	KRPPLRGVE	APC,CDC20,FZR1	0.9947	More...