DegronMD

Uniprot ID: O60682

Source protein: Musculin

Source gene: MSC

Class: DEG_APCC_DBOX_1

Location: 27:35

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9947

ASA_SCORE: 98.3333

COIL: 0.9119

CONS_SCORE: 0.343

DSS_SCORE: 0.6182

HELIX: 0.0383

FCONS_SCORE: 1.002

RIG_SCORE: 0.6151

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R28K	TCGA-BT-A42E	BLCA	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.7237
p.R28K	DO44030	BLCA	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.7237
p.R32C	TCGA-AA-3947	COAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.719
p.R32C	DO8192	COAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.719
p.R32H	SIDM01378	Ovarian Carcinoma	GDSC	KRPPLRGVE	DEG_APCC_DBOX_1	0.7133
p.R32H	ACH-000646	Ovarian Cancer	CCLE	KRPPLRGVE	DEG_APCC_DBOX_1	0.7133
p.P29L	TCGA-HU-A4GT	STAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.6471
p.P29L	DO48020	STAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.6471
p.E35G	TCGA-44-8119	LUAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.6087
p.E35G	DO24399	LUAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.6087
p.G33D	DO234389	ESAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.6087
p.V34I	TCGA-44-8117	LUAD	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	TCGA-NC-A5HR	LUSC	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	DO233766	GACA	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	DO24028	LUAD	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	DO219203	LUSC	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	SIDM00216	Colorectal Carcinoma	GDSC	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	SIDM01259	B-Lymphoblastic Leukemia	GDSC	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	ACH-000989	Colon/Colorectal Cancer	CCLE	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	ACH-001669	Leukemia	CCLE	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	ACH-002238	Leukemia	CCLE	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	SNU-175	large_intestine	COSMIC	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.V34I	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	KRPPLRGVE	DEG_APCC_DBOX_1	0.5965
p.S45T	TCGA-77-6844	LUSC	TCGA	KRPPLRGVE	DEG_APCC_DBOX_1	0.5
p.S45T	DO26818	LUSC	ICGC	KRPPLRGVE	DEG_APCC_DBOX_1	0.5

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Drug responses associated with MSC mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of KRPPLRGVE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60682	Musculin	DEG_APCC_DBOX_1	27:35	KRPPLRGVE	APC,CDC20,FZR1	0.9947	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRPPLRGVE

Degron related mutations and impact score

Drug responses associated with MSC mutations

All proteins holding degron of KRPPLRGVE