DegronMD - O60684(KPNA6)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P527S	TCGA-05-4396	LUAD	TCGA	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	511:524	Mutation rewiring degron network	0.25
p.P527S	DO23838	LUAD	ICGC	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	511:524	Mutation rewiring degron network	0.25
p.Q514P	TCGA-94-8491	LUSC	TCGA	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	511:524	Mutation altering degron motif	0.5924
p.D507N	TCGA-A6-5661	COAD	TCGA	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	511:524	Mutation rewiring degron network	0.2222
p.P513T	TCGA-AP-A0LF	UCEC	TCGA	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	511:524	Mutation altering degron motif	0.7031
p.D513N	DO225115	BRCA	ICGC	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	511:524	Mutation altering degron motif	0.6932
p.D504N	DO8634	COAD	ICGC	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	511:524	Mutation rewiring degron network	0.1389
p.T515M	DO230343	COCA	ICGC	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	511:524	Mutation altering degron motif	0.7423
p.Q511P	DO219174	LUSC	ICGC	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	511:524	Mutation altering degron motif	0.7035
p.S507N	DO220899	MELA	ICGC	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	511:524	Mutation rewiring degron network	0.2222
p.P510T	DO43610	UCEC	ICGC	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	511:524	Mutation rewiring degron network	0.3056
p.V504A	SIDM00191	Kidney Carcinoma	GDSC	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	511:524	Mutation rewiring degron network	0.1389
p.V504A	ACH-002090	Kidney Cancer	CCLE	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	511:524	Mutation rewiring degron network	0.1389
p.V504A	BB65-RCC	kidney	COSMIC	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	511:524	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons