DegronMD

Uniprot ID: O60684

Source protein: Importin subunit alpha-7

Source gene: KPNA6

Class: DEG_ODPH_VHL_1

Location: 511:524

E3 ligase: VHL

DEGRON score: 0.9018

ASA_SCORE: 83.6

COIL: 0.7637

CONS_SCORE: 0.4192

DSS_SCORE: 0.6234

HELIX: 0.1024

FCONS_SCORE: 0.8825

RIG_SCORE: 0.7808

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P527S	TCGA-05-4396	LUAD	TCGA	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	0.25
p.P527S	DO23838	LUAD	ICGC	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	0.25
p.Q514P	TCGA-94-8491	LUSC	TCGA	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	0.5924
p.D507N	TCGA-A6-5661	COAD	TCGA	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	0.2222
p.P513T	TCGA-AP-A0LF	UCEC	TCGA	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	0.7031
p.D513N	DO225115	BRCA	ICGC	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	0.6932
p.D504N	DO8634	COAD	ICGC	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	0.1389
p.T515M	DO230343	COCA	ICGC	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	0.7423
p.Q511P	DO219174	LUSC	ICGC	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	0.7035
p.S507N	DO220899	MELA	ICGC	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	0.2222
p.P510T	DO43610	UCEC	ICGC	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	0.3056
p.V504A	SIDM00191	Kidney Carcinoma	GDSC	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	0.1389
p.V504A	ACH-002090	Kidney Cancer	CCLE	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	0.1389
p.V504A	BB65-RCC	kidney	COSMIC	LAPQVDETQQQFIF	DEG_ODPH_VHL_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60684	Importin subunit alpha-7	DEG_ODPH_VHL_1	511:524	LAPQVDETQQQFIF	VHL	0.9018	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons