DegronMD - O60706(ABCC9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F799I	TCGA-55-6968	LUAD	TCGA	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation altering degron motif	0.7415
p.L797I	TCGA-77-8153	LUSC	TCGA	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation altering degron motif	0.6063
p.D795E	TCGA-A5-A0G1	UCEC	TCGA	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation rewiring degron network	0.3056
p.L790R	TCGA-L5-A4OT	ESCA	TCGA	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation rewiring degron network	0.1667
p.G800A	TCGA-LN-A7HX	ESCA	TCGA	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation altering degron motif	0.6429
p.L810V	DO50355	ESAD	ICGC	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation rewiring degron network	0.0833
p.Q792E	DO44419	HNSC	ICGC	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation rewiring degron network	0.2222
p.I796V	DO24245	LUAD	ICGC	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation altering degron motif	0.7076
p.A789V	DO48900	PBCA	ICGC	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation rewiring degron network	0.1389
p.A789V	DO38807	STAD	ICGC	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation rewiring degron network	0.1389
p.A789V	DO41572	UCEC	ICGC	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation rewiring degron network	0.1389
p.F798L	DO46905	RECA	ICGC	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation altering degron motif	0.6981
p.D807N	DO38099	SKCM	ICGC	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation rewiring degron network	0.1667
p.D807G	DO41020	UCEC	ICGC	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation rewiring degron network	0.1667
p.E807D	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation rewiring degron network	0.1667
p.E807D	ACH-000875	Lung Cancer	CCLE	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation rewiring degron network	0.1667
p.E807D	NCI-H2347	lung	COSMIC	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation rewiring degron network	0.1667
p.I810T	SIDM00228	Thyroid Gland Carcinoma	GDSC	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation rewiring degron network	0.0833
p.I810T	ACH-000897	Thyroid Cancer	CCLE	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation rewiring degron network	0.0833
p.Q802K	ACH-000779	Lung Cancer	CCLE	LLPFGD	LIG_APCC_ABBA_1	796:801	Mutation rewiring degron network	0.3056

Kaplan plot for ABCC9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABCC9

UniProt ID: O60706

Entrez ID: 10060

Protein name: ATP-binding cassette sub-family C member 9 (Sulfonylurea receptor 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ABCC9 in