DegronMD

Uniprot ID: O60706

Source protein: ATP-binding cassette sub-family C member 9

Source gene: ABCC9

Class: LIG_APCC_ABBA_1

Location: 796:801

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9704

ASA_SCORE: 54.9333

COIL: 0.868

CONS_SCORE: 0.5395

DSS_SCORE: 0.3626

HELIX: 0.0917

FCONS_SCORE: 0.8784

RIG_SCORE: 0.8086

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F799I	TCGA-55-6968	LUAD	TCGA	LLPFGD	LIG_APCC_ABBA_1	0.7415
p.L797I	TCGA-77-8153	LUSC	TCGA	LLPFGD	LIG_APCC_ABBA_1	0.6063
p.D795E	TCGA-A5-A0G1	UCEC	TCGA	LLPFGD	LIG_APCC_ABBA_1	0.3056
p.L790R	TCGA-L5-A4OT	ESCA	TCGA	LLPFGD	LIG_APCC_ABBA_1	0.1667
p.G800A	TCGA-LN-A7HX	ESCA	TCGA	LLPFGD	LIG_APCC_ABBA_1	0.6429
p.L810V	DO50355	ESAD	ICGC	LLPFGD	LIG_APCC_ABBA_1	0.0833
p.Q792E	DO44419	HNSC	ICGC	LLPFGD	LIG_APCC_ABBA_1	0.2222
p.I796V	DO24245	LUAD	ICGC	LLPFGD	LIG_APCC_ABBA_1	0.7076
p.A789V	DO48900	PBCA	ICGC	LLPFGD	LIG_APCC_ABBA_1	0.1389
p.A789V	DO38807	STAD	ICGC	LLPFGD	LIG_APCC_ABBA_1	0.1389
p.A789V	DO41572	UCEC	ICGC	LLPFGD	LIG_APCC_ABBA_1	0.1389
p.F798L	DO46905	RECA	ICGC	LLPFGD	LIG_APCC_ABBA_1	0.6981
p.D807N	DO38099	SKCM	ICGC	LLPFGD	LIG_APCC_ABBA_1	0.1667
p.D807G	DO41020	UCEC	ICGC	LLPFGD	LIG_APCC_ABBA_1	0.1667
p.E807D	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	LLPFGD	LIG_APCC_ABBA_1	0.1667
p.E807D	ACH-000875	Lung Cancer	CCLE	LLPFGD	LIG_APCC_ABBA_1	0.1667
p.E807D	NCI-H2347	lung	COSMIC	LLPFGD	LIG_APCC_ABBA_1	0.1667
p.I810T	SIDM00228	Thyroid Gland Carcinoma	GDSC	LLPFGD	LIG_APCC_ABBA_1	0.0833
p.I810T	ACH-000897	Thyroid Cancer	CCLE	LLPFGD	LIG_APCC_ABBA_1	0.0833
p.Q802K	ACH-000779	Lung Cancer	CCLE	LLPFGD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60706	ATP-binding cassette sub-family C member 9	LIG_APCC_ABBA_1	796:801	LLPFGD	APC,CDC20,FZR1	0.9704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons