DegronMD - O60711(LPXN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S78I	TCGA-A5-A0G1	UCEC	TCGA	LNVYSE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.2222
p.S78I	TCGA-AP-A0LS	UCEC	TCGA	LNVYSE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.2222
p.S78I	TCGA-DF-A2KN	UCEC	TCGA	LNVYSE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.2222
p.S59I	TCGA-A5-A0G2	UCEC	TCGA	LNVYSE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.0556
p.T68I	TCGA-DU-6392	LGG	TCGA	LNVYSE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.3056
p.E82K	TCGA-EA-A3HR	CESC	TCGA	LNVYSE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.1111
p.E77K	DO6326	CESC	ICGC	LNVYSE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.25
p.S81L	DO6655	CLLE	ICGC	LNVYSE	LIG_APCC_ABBA_1	69:74	Mutation blocking phosphorylation signal	0.5833
p.T63I	DO22237	LGG	ICGC	LNVYSE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.1667
p.L60I	DO228971	LICA	ICGC	LNVYSE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.0833
p.L69F	DO232224	PBCA	ICGC	LNVYSE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.587
p.S73I	DO223282	UCEC	ICGC	LNVYSE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.623
p.S73I	DO43178	UCEC	ICGC	LNVYSE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.623
p.S73I	DO42472	UCEC	ICGC	LNVYSE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.623
p.A63V	SIDM01307	Colorectal Carcinoma	GDSC	LNVYSE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.1667
p.P62L	SIDM01126	Small Cell Lung Carcinoma	GDSC	LNVYSE	LIG_APCC_ABBA_1	69:74	Mutation blocking phosphorylation signal	0.5833
p.P62L	SIDM01049	Non-Cancerous	GDSC	LNVYSE	LIG_APCC_ABBA_1	69:74	Mutation blocking phosphorylation signal	0.5833

Kaplan plot for LPXN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LPXN

UniProt ID: O60711

Entrez ID: 9404

Protein name: Leupaxin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LPXN in