DegronMD

Uniprot ID: O60711

Source protein: Leupaxin

Source gene: LPXN

Class: LIG_APCC_ABBA_1

Location: 69:74

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9918

ASA_SCORE: 94.3667

COIL: 0.7778

CONS_SCORE: 0.4737

DSS_SCORE: 0.5544

HELIX: 0.1845

FCONS_SCORE: 1.0104

RIG_SCORE: 0.7591

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S78I	TCGA-A5-A0G1	UCEC	TCGA	LNVYSE	LIG_APCC_ABBA_1	0.2222
p.S78I	TCGA-AP-A0LS	UCEC	TCGA	LNVYSE	LIG_APCC_ABBA_1	0.2222
p.S78I	TCGA-DF-A2KN	UCEC	TCGA	LNVYSE	LIG_APCC_ABBA_1	0.2222
p.S59I	TCGA-A5-A0G2	UCEC	TCGA	LNVYSE	LIG_APCC_ABBA_1	0.0556
p.T68I	TCGA-DU-6392	LGG	TCGA	LNVYSE	LIG_APCC_ABBA_1	0.3056
p.E82K	TCGA-EA-A3HR	CESC	TCGA	LNVYSE	LIG_APCC_ABBA_1	0.1111
p.E77K	DO6326	CESC	ICGC	LNVYSE	LIG_APCC_ABBA_1	0.25
p.S81L	DO6655	CLLE	ICGC	LNVYSE	LIG_APCC_ABBA_1	0.5833
p.T63I	DO22237	LGG	ICGC	LNVYSE	LIG_APCC_ABBA_1	0.1667
p.L60I	DO228971	LICA	ICGC	LNVYSE	LIG_APCC_ABBA_1	0.0833
p.L69F	DO232224	PBCA	ICGC	LNVYSE	LIG_APCC_ABBA_1	0.587
p.S73I	DO223282	UCEC	ICGC	LNVYSE	LIG_APCC_ABBA_1	0.623
p.S73I	DO43178	UCEC	ICGC	LNVYSE	LIG_APCC_ABBA_1	0.623
p.S73I	DO42472	UCEC	ICGC	LNVYSE	LIG_APCC_ABBA_1	0.623
p.A63V	SIDM01307	Colorectal Carcinoma	GDSC	LNVYSE	LIG_APCC_ABBA_1	0.1667
p.P62L	SIDM01126	Small Cell Lung Carcinoma	GDSC	LNVYSE	LIG_APCC_ABBA_1	0.5833
p.P62L	SIDM01049	Non-Cancerous	GDSC	LNVYSE	LIG_APCC_ABBA_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60711	Leupaxin	LIG_APCC_ABBA_1	69:74	LNVYSE	APC,CDC20,FZR1	0.9918	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons