DegronMD - O60729(CDC14B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L488I	TCGA-AZ-4315	COAD	TCGA	VLR	DEG_APCC_TPR_1	496:498	Mutation rewiring degron network	0.1111
p.L488I	DO8842	COAD	ICGC	VLR	DEG_APCC_TPR_1	496:498	Mutation rewiring degron network	0.1111
p.R498H	TCGA-B7-A5TI	STAD	TCGA	VLR	DEG_APCC_TPR_1	496:498	Mutation altering degron motif	0.8244
p.R498H	TCGA-BR-A453	STAD	TCGA	VLR	DEG_APCC_TPR_1	496:498	Mutation altering degron motif	0.8244
p.R498H	SIDM01090	Colorectal Carcinoma	GDSC	VLR	DEG_APCC_TPR_1	496:498	Mutation altering degron motif	0.8244
p.R498H	RKO	large intestine	COSMIC	VLR	DEG_APCC_TPR_1	496:498	Mutation altering degron motif	0.8244
p.L497F	TCGA-C5-A7CK	CESC	TCGA	VLR	DEG_APCC_TPR_1	496:498	Mutation altering degron motif	0.6981
p.L497F	DO49000	CESC	ICGC	VLR	DEG_APCC_TPR_1	496:498	Mutation altering degron motif	0.6981
p.R498C	TCGA-D9-A3Z3	SKCM	TCGA	VLR	DEG_APCC_TPR_1	496:498	Mutation altering degron motif	0.8301
p.R498C	TCGA-ZF-AA4W	BLCA	TCGA	VLR	DEG_APCC_TPR_1	496:498	Mutation altering degron motif	0.8301
p.R498C	DO219089	BLCA	ICGC	VLR	DEG_APCC_TPR_1	496:498	Mutation altering degron motif	0.8301
p.R498C	DO233728	GACA	ICGC	VLR	DEG_APCC_TPR_1	496:498	Mutation altering degron motif	0.8301
p.R498C	DO37563	SKCM	ICGC	VLR	DEG_APCC_TPR_1	496:498	Mutation altering degron motif	0.8301
p.R498C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VLR	DEG_APCC_TPR_1	496:498	Mutation altering degron motif	0.8301
p.R498C	ACH-001127	Leukemia	CCLE	VLR	DEG_APCC_TPR_1	496:498	Mutation altering degron motif	0.8301
p.R498C	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VLR	DEG_APCC_TPR_1	496:498	Mutation altering degron motif	0.8301
p.L488F	TCGA-E6-A1LX	UCEC	TCGA	VLR	DEG_APCC_TPR_1	496:498	Mutation rewiring degron network	0.1111
p.L488F	TCGA-IB-7651	PAAD	TCGA	VLR	DEG_APCC_TPR_1	496:498	Mutation rewiring degron network	0.1111
p.L488F	DO46657	PAAD	ICGC	VLR	DEG_APCC_TPR_1	496:498	Mutation rewiring degron network	0.1111
p.L488F	DO41020	UCEC	ICGC	VLR	DEG_APCC_TPR_1	496:498	Mutation rewiring degron network	0.1111
p.I490F	TCGA-EB-A41A	SKCM	TCGA	VLR	DEG_APCC_TPR_1	496:498	Mutation rewiring degron network	0.1667
p.I490F	DO37429	SKCM	ICGC	VLR	DEG_APCC_TPR_1	496:498	Mutation rewiring degron network	0.1667
p.S489C	TCGA-JX-A3Q0	CESC	TCGA	VLR	DEG_APCC_TPR_1	496:498	Mutation rewiring degron network	0.1389
p.S489C	DO51607	CESC	ICGC	VLR	DEG_APCC_TPR_1	496:498	Mutation rewiring degron network	0.1389
p.S489C	DO11854	GBM	ICGC	VLR	DEG_APCC_TPR_1	496:498	Mutation rewiring degron network	0.1389
p.K494E	SIDM00202	Ewing's Sarcoma	GDSC	VLR	DEG_APCC_TPR_1	496:498	Mutation rewiring degron network	0.2778
p.K494E	EW-3	bone	COSMIC	VLR	DEG_APCC_TPR_1	496:498	Mutation rewiring degron network	0.2778

Kaplan plot for CDC14B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDC14B

UniProt ID: O60729

Entrez ID: 8555

Protein name: Dual specificity protein phosphatase CDC14B (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDC14B in