DegronMD

Uniprot ID: O60729

Source protein: Dual specificity protein phosphatase CDC14B

Source gene: CDC14B

Class: DEG_APCC_TPR_1

Location: 496:498

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9032

ASA_SCORE: 136.4333

COIL: 0.9433

CONS_SCORE: 0.2836

DSS_SCORE: 0.8864

HELIX: 0.036

FCONS_SCORE: 0.9202

RIG_SCORE: 0.79

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L488I	TCGA-AZ-4315	COAD	TCGA	VLR	DEG_APCC_TPR_1	0.1111
p.L488I	DO8842	COAD	ICGC	VLR	DEG_APCC_TPR_1	0.1111
p.R498H	TCGA-B7-A5TI	STAD	TCGA	VLR	DEG_APCC_TPR_1	0.8244
p.R498H	TCGA-BR-A453	STAD	TCGA	VLR	DEG_APCC_TPR_1	0.8244
p.R498H	SIDM01090	Colorectal Carcinoma	GDSC	VLR	DEG_APCC_TPR_1	0.8244
p.R498H	RKO	large_intestine	COSMIC	VLR	DEG_APCC_TPR_1	0.8244
p.L497F	TCGA-C5-A7CK	CESC	TCGA	VLR	DEG_APCC_TPR_1	0.6981
p.L497F	DO49000	CESC	ICGC	VLR	DEG_APCC_TPR_1	0.6981
p.R498C	TCGA-D9-A3Z3	SKCM	TCGA	VLR	DEG_APCC_TPR_1	0.8301
p.R498C	TCGA-ZF-AA4W	BLCA	TCGA	VLR	DEG_APCC_TPR_1	0.8301
p.R498C	DO219089	BLCA	ICGC	VLR	DEG_APCC_TPR_1	0.8301
p.R498C	DO233728	GACA	ICGC	VLR	DEG_APCC_TPR_1	0.8301
p.R498C	DO37563	SKCM	ICGC	VLR	DEG_APCC_TPR_1	0.8301
p.R498C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VLR	DEG_APCC_TPR_1	0.8301
p.R498C	ACH-001127	Leukemia	CCLE	VLR	DEG_APCC_TPR_1	0.8301
p.R498C	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VLR	DEG_APCC_TPR_1	0.8301
p.L488F	TCGA-E6-A1LX	UCEC	TCGA	VLR	DEG_APCC_TPR_1	0.1111
p.L488F	TCGA-IB-7651	PAAD	TCGA	VLR	DEG_APCC_TPR_1	0.1111
p.L488F	DO46657	PAAD	ICGC	VLR	DEG_APCC_TPR_1	0.1111
p.L488F	DO41020	UCEC	ICGC	VLR	DEG_APCC_TPR_1	0.1111
p.I490F	TCGA-EB-A41A	SKCM	TCGA	VLR	DEG_APCC_TPR_1	0.1667
p.I490F	DO37429	SKCM	ICGC	VLR	DEG_APCC_TPR_1	0.1667
p.S489C	TCGA-JX-A3Q0	CESC	TCGA	VLR	DEG_APCC_TPR_1	0.1389
p.S489C	DO51607	CESC	ICGC	VLR	DEG_APCC_TPR_1	0.1389
p.S489C	DO11854	GBM	ICGC	VLR	DEG_APCC_TPR_1	0.1389
p.K494E	SIDM00202	Ewing's Sarcoma	GDSC	VLR	DEG_APCC_TPR_1	0.2778
p.K494E	EW-3	bone	COSMIC	VLR	DEG_APCC_TPR_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60729	Dual specificity protein phosphatase CDC14B	DEG_APCC_TPR_1	496:498	VLR	APC,CDC20,FZR1	0.9032	More...
Q14764	Major vault protein	DEG_APCC_TPR_1	891:893	VLR	APC,CDC20,FZR1	0.5797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons