DegronMD - Q14764(MVP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R893P	TCGA-95-7562	LUAD	TCGA	VLR	DEG_APCC_TPR_1	891:893	Mutation altering degron motif	0.7512
p.R893P	DO51196	LUAD	ICGC	VLR	DEG_APCC_TPR_1	891:893	Mutation altering degron motif	0.7512
p.V371A	TCGA-AX-A2HD	UCEC	TCGA	IRGPLEYVP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.2222
p.V371A	DO42608	UCEC	ICGC	IRGPLEYVP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.2222
p.R360C	TCGA-B5-A11E	UCEC	TCGA	IRGPLEYVP	DEG_APCC_DBOX_1	359:367	Mutation altering degron motif	0.8301
p.R360C	DO41644	UCEC	ICGC	IRGPLEYVP	DEG_APCC_DBOX_1	359:367	Mutation altering degron motif	0.8301
p.E372G	TCGA-CV-7423	HNSC	TCGA	IRGPLEYVP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1944
p.E372G	DO14246	HNSC	ICGC	IRGPLEYVP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1944
p.E364K	TCGA-EO-A3KX	UCEC	TCGA	IRGPLEYVP	DEG_APCC_DBOX_1	359:367	Mutation altering degron motif	0.591
p.E364K	DO227564	PACA	ICGC	IRGPLEYVP	DEG_APCC_DBOX_1	359:367	Mutation altering degron motif	0.591
p.E364K	DO219774	UCEC	ICGC	IRGPLEYVP	DEG_APCC_DBOX_1	359:367	Mutation altering degron motif	0.591
p.R893C	TCGA-FI-A2D0	UCEC	TCGA	VLR	DEG_APCC_TPR_1	891:893	Mutation altering degron motif	0.8301
p.R893C	DO43891	UCEC	ICGC	VLR	DEG_APCC_TPR_1	891:893	Mutation altering degron motif	0.8301
p.R893C	SIDM01139	Pancreatic Carcinoma	GDSC	VLR	DEG_APCC_TPR_1	891:893	Mutation altering degron motif	0.8301
p.R893C	SIDM00262	Ewing's Sarcoma	GDSC	VLR	DEG_APCC_TPR_1	891:893	Mutation altering degron motif	0.8301
p.R893C	SIDM01168	Colorectal Carcinoma	GDSC	VLR	DEG_APCC_TPR_1	891:893	Mutation altering degron motif	0.8301
p.P890L	TCGA-FI-A2D5	UCEC	TCGA	VLR	DEG_APCC_TPR_1	891:893	Mutation rewiring degron network	0.3056
p.P890L	DO41331	UCEC	ICGC	VLR	DEG_APCC_TPR_1	891:893	Mutation rewiring degron network	0.3056
p.Q881E	TCGA-Q1-A5R2	CESC	TCGA	VLR	DEG_APCC_TPR_1	891:893	Mutation rewiring degron network	0.0556
p.Q881E	DO49003	CESC	ICGC	VLR	DEG_APCC_TPR_1	891:893	Mutation rewiring degron network	0.0556
p.P883S	TCGA-WE-A8K5	SKCM	TCGA	VLR	DEG_APCC_TPR_1	891:893	Mutation rewiring degron network	0.1111
p.P883S	DO51282	SKCM	ICGC	VLR	DEG_APCC_TPR_1	891:893	Mutation rewiring degron network	0.1111
p.Y365S	SIDM02050	Colorectal Carcinoma	GDSC	IRGPLEYVP	DEG_APCC_DBOX_1	359:367	Mutation altering degron motif	0.6009
p.D885G	SIDM00032	Bladder Carcinoma	GDSC	VLR	DEG_APCC_TPR_1	891:893	Mutation rewiring degron network	0.1667
p.V366A	ACH-000848	Liver Cancer	CCLE	IRGPLEYVP	DEG_APCC_DBOX_1	359:367	Mutation altering degron motif	0.6936

Kaplan plot for MVP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MVP

UniProt ID: Q14764

Entrez ID: 9961

Protein name: Major vault protein (MVP) (Lung resistance-related protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MVP in