DegronMD

Uniprot ID: Q14764

Source protein: Major vault protein

Source gene: MVP

Class: DEG_APCC_DBOX_1

Location: 359:367

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8849

ASA_SCORE: 55.0333

COIL: 0.4803

CONS_SCORE: 0.7537

DSS_SCORE: 0.2803

HELIX: 0.0079

FCONS_SCORE: 1.2331

RIG_SCORE: 0.7643

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V371A	TCGA-AX-A2HD	UCEC	TCGA	IRGPLEYVP	DEG_APCC_DBOX_1	0.2222
p.V371A	DO42608	UCEC	ICGC	IRGPLEYVP	DEG_APCC_DBOX_1	0.2222
p.R360C	TCGA-B5-A11E	UCEC	TCGA	IRGPLEYVP	DEG_APCC_DBOX_1	0.8301
p.R360C	DO41644	UCEC	ICGC	IRGPLEYVP	DEG_APCC_DBOX_1	0.8301
p.E372G	TCGA-CV-7423	HNSC	TCGA	IRGPLEYVP	DEG_APCC_DBOX_1	0.1944
p.E372G	DO14246	HNSC	ICGC	IRGPLEYVP	DEG_APCC_DBOX_1	0.1944
p.E364K	TCGA-EO-A3KX	UCEC	TCGA	IRGPLEYVP	DEG_APCC_DBOX_1	0.591
p.E364K	DO227564	PACA	ICGC	IRGPLEYVP	DEG_APCC_DBOX_1	0.591
p.E364K	DO219774	UCEC	ICGC	IRGPLEYVP	DEG_APCC_DBOX_1	0.591
p.Y365S	SIDM02050	Colorectal Carcinoma	GDSC	IRGPLEYVP	DEG_APCC_DBOX_1	0.6009
p.V366A	ACH-000848	Liver Cancer	CCLE	IRGPLEYVP	DEG_APCC_DBOX_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14764	Major vault protein	DEG_APCC_DBOX_1	359:367	IRGPLEYVP	APC,CDC20,FZR1	0.8849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons