DegronMD

Uniprot ID: Q14764

Source protein: Major vault protein

Source gene: MVP

Class: DEG_APCC_TPR_1

Location: 891:893

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5797

ASA_SCORE: 103.7333

COIL: 0.7097

CONS_SCORE: 0.085

DSS_SCORE: 0.9527

HELIX: 0.0143

FCONS_SCORE: 0.7453

RIG_SCORE: 0.7824

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R893P	TCGA-95-7562	LUAD	TCGA	VLR	DEG_APCC_TPR_1	0.7512
p.R893P	DO51196	LUAD	ICGC	VLR	DEG_APCC_TPR_1	0.7512
p.R893C	TCGA-FI-A2D0	UCEC	TCGA	VLR	DEG_APCC_TPR_1	0.8301
p.R893C	DO43891	UCEC	ICGC	VLR	DEG_APCC_TPR_1	0.8301
p.R893C	SIDM01139	Pancreatic Carcinoma	GDSC	VLR	DEG_APCC_TPR_1	0.8301
p.R893C	SIDM00262	Ewing's Sarcoma	GDSC	VLR	DEG_APCC_TPR_1	0.8301
p.R893C	SIDM01168	Colorectal Carcinoma	GDSC	VLR	DEG_APCC_TPR_1	0.8301
p.P890L	TCGA-FI-A2D5	UCEC	TCGA	VLR	DEG_APCC_TPR_1	0.3056
p.P890L	DO41331	UCEC	ICGC	VLR	DEG_APCC_TPR_1	0.3056
p.Q881E	TCGA-Q1-A5R2	CESC	TCGA	VLR	DEG_APCC_TPR_1	0.0556
p.Q881E	DO49003	CESC	ICGC	VLR	DEG_APCC_TPR_1	0.0556
p.P883S	TCGA-WE-A8K5	SKCM	TCGA	VLR	DEG_APCC_TPR_1	0.1111
p.P883S	DO51282	SKCM	ICGC	VLR	DEG_APCC_TPR_1	0.1111
p.D885G	SIDM00032	Bladder Carcinoma	GDSC	VLR	DEG_APCC_TPR_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60729	Dual specificity protein phosphatase CDC14B	DEG_APCC_TPR_1	496:498	VLR	APC,CDC20,FZR1	0.9032	More...
Q14764	Major vault protein	DEG_APCC_TPR_1	891:893	VLR	APC,CDC20,FZR1	0.5797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons