DegronMD - O60739(EIF1B)

EIF1B

Please click HERE for better display.

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A14V	TCGA-A5-A1OF	UCEC	TCGA	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.5825
p.A14V	DO42568	UCEC	ICGC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.5825
p.S9Y	TCGA-AJ-A5DW	UCEC	TCGA	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation blocking phosphorylation signal	0.75
p.S9Y	DO50075	UCEC	ICGC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation blocking phosphorylation signal	0.75
p.P24S	TCGA-EE-A29N	SKCM	TCGA	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation rewiring degron network	0.0833
p.P24S	DO38001	SKCM	ICGC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation rewiring degron network	0.0833
p.D11Y	TCGA-ER-A19B	SKCM	TCGA	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.6214
p.D11Y	DO47491	SKCM	ICGC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.6214
p.K18N	TCGA-MN-A4N4	LUAD	TCGA	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation blocking ubiquitination signal	0.6944
p.K18N	DO26250	LUAD	ICGC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation blocking ubiquitination signal	0.6944
p.D20E	TCGA-V4-A9EM	UVM	TCGA	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation rewiring degron network	0.1944
p.P12L	DO233652	GACA	ICGC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.6471
p.D11N	SIDM00789	Colorectal Carcinoma	GDSC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.5821
p.D11N	HCT-15	large intestine	COSMIC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.5821
p.D15N	ACH-000472	Head and Neck Cancer	CCLE	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.6932

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc