DegronMD

Uniprot ID: O60739

Source protein: Eukaryotic translation initiation factor 1b

Source gene: EIF1B

Class: LIG_APCC_ABBA_1

Location: 10:15

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.995

ASA_SCORE: 54.65

COIL: 0.736

CONS_SCORE: 0.6557

DSS_SCORE: 0.425

HELIX: 0.2013

FCONS_SCORE: 1.627

RIG_SCORE: 0.7665

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A14V	TCGA-A5-A1OF	UCEC	TCGA	FDPFAD	LIG_APCC_ABBA_1	0.5825
p.A14V	DO42568	UCEC	ICGC	FDPFAD	LIG_APCC_ABBA_1	0.5825
p.S9Y	TCGA-AJ-A5DW	UCEC	TCGA	FDPFAD	LIG_APCC_ABBA_1	0.75
p.S9Y	DO50075	UCEC	ICGC	FDPFAD	LIG_APCC_ABBA_1	0.75
p.P24S	TCGA-EE-A29N	SKCM	TCGA	FDPFAD	LIG_APCC_ABBA_1	0.0833
p.P24S	DO38001	SKCM	ICGC	FDPFAD	LIG_APCC_ABBA_1	0.0833
p.D11Y	TCGA-ER-A19B	SKCM	TCGA	FDPFAD	LIG_APCC_ABBA_1	0.6214
p.D11Y	DO47491	SKCM	ICGC	FDPFAD	LIG_APCC_ABBA_1	0.6214
p.K18N	TCGA-MN-A4N4	LUAD	TCGA	FDPFAD	LIG_APCC_ABBA_1	0.6944
p.K18N	DO26250	LUAD	ICGC	FDPFAD	LIG_APCC_ABBA_1	0.6944
p.D20E	TCGA-V4-A9EM	UVM	TCGA	FDPFAD	LIG_APCC_ABBA_1	0.1944
p.P12L	DO233652	GACA	ICGC	FDPFAD	LIG_APCC_ABBA_1	0.6471
p.D11N	SIDM00789	Colorectal Carcinoma	GDSC	FDPFAD	LIG_APCC_ABBA_1	0.5821
p.D11N	HCT-15	large_intestine	COSMIC	FDPFAD	LIG_APCC_ABBA_1	0.5821
p.D15N	ACH-000472	Head and Neck Cancer	CCLE	FDPFAD	LIG_APCC_ABBA_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41567	Eukaryotic translation initiation factor 1	LIG_APCC_ABBA_1	10:15	FDPFAD	APC,CDC20,FZR1	0.9992	More...
O60739	Eukaryotic translation initiation factor 1b	LIG_APCC_ABBA_1	10:15	FDPFAD	APC,CDC20,FZR1	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons