DegronMD - P41567(EIF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D21Y	TCGA-97-A4M7	LUAD	TCGA	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation rewiring degron network	0.1667
p.D21Y	DO45386	LUAD	ICGC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation rewiring degron network	0.1667
p.P12S	TCGA-AX-A1CE	UCEC	TCGA	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.6752
p.P12S	DO42280	UCEC	ICGC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.6752
p.D21G	TCGA-B5-A3FC	UCEC	TCGA	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation rewiring degron network	0.1667
p.D21G	DO41871	UCEC	ICGC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation rewiring degron network	0.1667
p.Q5H	TCGA-V5-A7RE	ESCA	TCGA	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation rewiring degron network	0.1944
p.S9C	TCGA-VQ-A91S	STAD	TCGA	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation blocking phosphorylation signal	0.75
p.S9C	DO222352	STAD	ICGC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation blocking phosphorylation signal	0.75
p.D11H	DO229379	BTCA	ICGC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.6577
p.D11E	DO234274	ESAD	ICGC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.5647
p.L23R	DO48716	LIRI	ICGC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation rewiring degron network	0.1111
p.L23H	SIDM00845	Burkitt's Lymphoma	GDSC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation rewiring degron network	0.1111
p.S9F	SIDM01245	T-Lymphoblastic Leukemia	GDSC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation blocking phosphorylation signal	0.75
p.S9F	SIDM00991	T-Lymphoblastic Leukemia	GDSC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation blocking phosphorylation signal	0.75
p.S9F	ACH-000519	Leukemia	CCLE	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation blocking phosphorylation signal	0.75
p.S9F	ACH-002216	Leukemia	CCLE	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation blocking phosphorylation signal	0.75
p.S9F	BE-13	haematopoietic and lymphoid tissue	COSMIC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation blocking phosphorylation signal	0.75
p.D15N	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.6932
p.D15N	ACH-000929	Lung Cancer	CCLE	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.6932
p.D15N	NCI-H2110	lung	COSMIC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.6932
p.F10I	SIDM01387	Small Cell Lung Carcinoma	GDSC	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.6304
p.F10I	ACH-000921	Lung Cancer	CCLE	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation altering degron motif	0.6304
p.A25V	ACH-000960	Leukemia	CCLE	FDPFAD	LIG_APCC_ABBA_1	10:15	Mutation rewiring degron network	0.0556

Kaplan plot for EIF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EIF1

UniProt ID: P41567

Entrez ID: 10209

Protein name: Eukaryotic translation initiation factor 1 (eIF1) (A121) (Protein translation factor SUI1 homolog) (Sui1iso1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EIF1 in