DegronMD

Uniprot ID: P41567

Source protein: Eukaryotic translation initiation factor 1

Source gene: EIF1

Class: LIG_APCC_ABBA_1

Location: 10:15

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9992

ASA_SCORE: 53.5333

COIL: 0.7465

CONS_SCORE: 0.6781

DSS_SCORE: 0.3722

HELIX: 0.1898

FCONS_SCORE: 1.6916

RIG_SCORE: 0.7431

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D21Y	TCGA-97-A4M7	LUAD	TCGA	FDPFAD	LIG_APCC_ABBA_1	0.1667
p.D21Y	DO45386	LUAD	ICGC	FDPFAD	LIG_APCC_ABBA_1	0.1667
p.P12S	TCGA-AX-A1CE	UCEC	TCGA	FDPFAD	LIG_APCC_ABBA_1	0.6752
p.P12S	DO42280	UCEC	ICGC	FDPFAD	LIG_APCC_ABBA_1	0.6752
p.D21G	TCGA-B5-A3FC	UCEC	TCGA	FDPFAD	LIG_APCC_ABBA_1	0.1667
p.D21G	DO41871	UCEC	ICGC	FDPFAD	LIG_APCC_ABBA_1	0.1667
p.Q5H	TCGA-V5-A7RE	ESCA	TCGA	FDPFAD	LIG_APCC_ABBA_1	0.1944
p.S9C	TCGA-VQ-A91S	STAD	TCGA	FDPFAD	LIG_APCC_ABBA_1	0.75
p.S9C	DO222352	STAD	ICGC	FDPFAD	LIG_APCC_ABBA_1	0.75
p.D11H	DO229379	BTCA	ICGC	FDPFAD	LIG_APCC_ABBA_1	0.6577
p.D11E	DO234274	ESAD	ICGC	FDPFAD	LIG_APCC_ABBA_1	0.5647
p.L23R	DO48716	LIRI	ICGC	FDPFAD	LIG_APCC_ABBA_1	0.1111
p.L23H	SIDM00845	Burkitt's Lymphoma	GDSC	FDPFAD	LIG_APCC_ABBA_1	0.1111
p.S9F	SIDM01245	T-Lymphoblastic Leukemia	GDSC	FDPFAD	LIG_APCC_ABBA_1	0.75
p.S9F	SIDM00991	T-Lymphoblastic Leukemia	GDSC	FDPFAD	LIG_APCC_ABBA_1	0.75
p.S9F	ACH-000519	Leukemia	CCLE	FDPFAD	LIG_APCC_ABBA_1	0.75
p.S9F	ACH-002216	Leukemia	CCLE	FDPFAD	LIG_APCC_ABBA_1	0.75
p.S9F	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	FDPFAD	LIG_APCC_ABBA_1	0.75
p.D15N	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	FDPFAD	LIG_APCC_ABBA_1	0.6932
p.D15N	ACH-000929	Lung Cancer	CCLE	FDPFAD	LIG_APCC_ABBA_1	0.6932
p.D15N	NCI-H2110	lung	COSMIC	FDPFAD	LIG_APCC_ABBA_1	0.6932
p.F10I	SIDM01387	Small Cell Lung Carcinoma	GDSC	FDPFAD	LIG_APCC_ABBA_1	0.6304
p.F10I	ACH-000921	Lung Cancer	CCLE	FDPFAD	LIG_APCC_ABBA_1	0.6304
p.A25V	ACH-000960	Leukemia	CCLE	FDPFAD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41567	Eukaryotic translation initiation factor 1	LIG_APCC_ABBA_1	10:15	FDPFAD	APC,CDC20,FZR1	0.9992	More...
O60739	Eukaryotic translation initiation factor 1b	LIG_APCC_ABBA_1	10:15	FDPFAD	APC,CDC20,FZR1	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons